Thiabendazole (Thiabendazole)

Thiabendazole is an anthelmintic used to treat intestinal infestations by pinworms or other worms. Prescribed internally; can sometimes cause vomiting, dizziness and stomach discomfort. Trade name: Mintezol.

Thiabendazole belongs to the group of benzimidazoles and has a wide spectrum of anthelmintic activity. It is effective against nematodes (pinworms, roundworms, whipworms, trichinella), and also suppresses the larval stages of cestodes.

The mechanism of action of thiabendazole is to disrupt the energy supply processes of helminths by suppressing fumarate reductase activity. This leads to depletion of glycogen and glucose stores in the parasites.

After oral administration, thiabendazole is well absorbed from the gastrointestinal tract, reaching maximum plasma concentrations after 1-2 hours. The half-life is approximately 3 hours. It is excreted mainly in the urine unchanged.

Thiabendazole is used to treat enterobiasis, ascariasis, trichuriasis, hookworm, and trichinosis. The course of treatment is usually 1-3 days.

Side effects include nausea, vomiting, diarrhea, and dizziness. Allergic reactions are rarely possible. Contraindicated during pregnancy.

Thiabendazole is available in tablets and suspensions for oral administration. The most famous brand is Mintezol.

Thiabendazole is an anthelmintic drug that is used to treat intestinal infestations caused by pinworms and other types of worms. It is taken orally and may cause nausea, vomiting, and dizziness in some patients. The trade name of the drug is Mintezol.

The mechanism of action of thiabendazole is to block the enzyme necessary for the synthesis of glycolipids in the cells of worms, which leads to their death. The drug is also active against certain types of protozoa, such as Giardia and Amoeba.

Thiabendazole is usually prescribed for infestations caused by pinworms, roundworms, whipworms and some other types of helminths. It is also used in the treatment of giardiasis and amoebiasis.

This medicine may cause side effects such as nausea, vomiting, dizziness, diarrhea, or constipation. It is also possible to experience allergic reactions such as rash, itching or hives.

To treat intestinal helminth infestation, it is recommended to consult a doctor and follow his recommendations. Thiabendazole can be prescribed only after tests have been carried out to determine the type of worms and their sensitivity to the drug.

Thiabendazole (a drug for the prevention of worms in animals), TBZA (trade name - as a drug, as well as its trade name in French - benzimidazole, another trade name - Benzimidazole; name according to the nomenclature newly adopted by the WHO Commission on Antibiotics (No. lat . - under this number the chemical compound was included in the catalog of chemically identical substances, taxonomic number 155976-3).

For humans, thiabendazole was synthesized in 1949 under the direction of Joachim Stehrnberg from benzimidazol-2-thione.[1]

Currently approved for use and registered in Russia