Tiklo

Tiklo: Antiplatelet agent from Poland with a wide range of applications

Ticlo (international name: Ticlopidine) is a pharmaceutical drug belonging to the group of antiplatelet agents. This drug is manufactured in Poland by Schwartz Pharma Sp. z.o.o. and has several synonyms, including Aklotin, Tagren and Tiklid. It is presented in the form of film-coated tablets containing 250 mg of the active substance - Ticlopidine.

Tiklo is used in various fields of medicine. It is effective in the treatment of acute myocardial infarction, unstable angina, transient cerebrovascular accidents and conditions after heart valve replacement, coronary artery bypass grafting and angioplasty. The drug is also indicated in cases of severe atherosclerosis of the peripheral arteries, intermittent claudication, chronic glomerulonephritis, sickle cell anemia and microangiopathy in diabetes mellitus.

However, Tiklo has a number of contraindications. It is not recommended to use the drug in case of hypersensitivity to ticlopidine, acute peptic ulcers of the stomach, risk of bleeding during exacerbation of peptic ulcer of the stomach and duodenum, intracranial hemorrhage, hemorrhagic diathesis, neutropenia, thrombocytopenia, severe liver dysfunction, acute stroke, as well as during pregnancy and lactation .

Side effects may occur when using Tiklo. They may include gastrointestinal disorders, less commonly - bleeding, hemorrhagic rashes, hematuria, thrombocytopenia, neutropenia, severe agranulocytosis, pancytopenia, dizziness, headache, tinnitus, asthenia, increased serum cholesterol and triglycerides, increased transaminase activity and alkaline phosphatase, cholestatic jaundice, rash and itching.

Ticlo may also interact with other drugs. It increases the inhibitory effect of aspirin and other NSAID drugs on platelet aggregation, which increases the risk of bleeding. Antacids, by reducing absorption, can reduce Ticlo plasma concentrations by 18%. The drug cimetidine blocks microsomal oxidation. I apologize, but my previous answer was cut off. Here's the continuation:

The drug cimetidine blocks microsomal oxidation of ticlopidine in the liver, which can lead to an increase in its concentration in the body. Tiklo may also affect the metabolism of other medications, so you should consult your doctor before using it and inform about all medications you are taking.

Since my information is current only as of September 2021, it is recommended that you consult current sources of information or consult a healthcare professional for more detailed and current information about Ticlo (Ticlopidine).