Thiogamma solution for droppers

Various medications can be used to regulate metabolism and treat neuropathy. Doctors often prescribe the drug Thiogamma, which contains thioctic (lipoic, alpha-lipoic) acid, which has properties similar to B vitamins. Reading the instructions for use of the drug will help you obtain information about the indications, side effects, and method of taking the medicine.

Instructions for use of Thiogamma

Thiogamma tablets are drugs that regulate the metabolism of carbohydrates and lipids in the body. This effect is achieved due to the content of lipoic acid. It is one of the substances produced by the body, but if it is deficient, metabolism slows down, and problems such as obesity and diabetes begin. Medicines based on thioctic acid will help in the treatment of these pathologies and polyneuropathy.

Composition and release form

The drug Thiogamma is available in the form of tablets, solution for infusion and concentrate for the preparation of solution for infusion. The tablets are covered with a light yellow shell, with yellow and white inclusions of varying saturation, the shape is oblong and biconvex, there are marks on both sides, and a light yellow tablet core is visible on the cross section. Solution for infusion is yellow-green or light yellow, transparent. The concentrate is a transparent yellow or green-yellow solution in glass ampoules. Composition of the drug:

Thioctic acid 600 mg

Hypromellose, colloidal silicon dioxide, microcrystalline cellulose, lactose monohydrate, carmellose sodium, talc, simethicone, magnesium stearate, macrogol 6000, sodium lauryl sulfate

Meglumine thioctate (equivalent to 600 mg thioctic acid)

Macrogol 300, meglumine, water

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug is thioctic acid, which belongs to the category of endogenous antioxidants that bind free radicals. Inside the human body, it appears in the process of oxidative decarboxylation of alpha-keto acids. The medication has a metabolic and antioxidant effect, lowers blood sugar levels, increases glycogen reserves in the liver and reduces insulin resistance.

Taking Thiogamma affects carbohydrate and lipid metabolism, stimulates liver function and blood circulation, affects cholesterol metabolism, and removes toxins in case of poisoning with heavy metal salts. The medication combines hypoglycemic and hypocholesterolemic effects, is a hepatoprotector, and optimizes neuronal trophism. Taking thioctic acid reduces the level of glycation products, stimulates endoneurial blood flow, increases glutathione levels, providing improvement in the condition of peripheral nerve fibers in diabetic polyneuropathy.

The medication is completely absorbed in the gastrointestinal tract in a short period. Taking it with food reduces its absorption. Metabolism of Thiogamma occurs in the liver through side chain oxidation followed by conjugation. The drug is excreted mainly by the kidneys (up to 90%). The half-life of the substance is about 25 minutes. A minimal amount of the drug components may be found unchanged in the urine.

Indications for use

Thiogamma has indications for use due to the properties of the active substance of the drug. The main reasons for prescribing the drug:

1. neuropathy due to diabetes;
2. painful conditions of the liver: fatty degeneration processes of hepatocytes, cirrhosis and hepatitis of various origins;
3. destruction of nerve trunks caused by alcohol;
4. poisoning with severe symptoms (mushrooms, heavy metal salts);
5. sensorimotor or peripheral polyneuropathy.

Directions for use and dosage

Depending on the form of the drug, the method of administration and dosage differ. It is especially important to follow the rules when using the solution and concentrate to prepare the solution. After removing the bottle from the box, it is necessary to immediately cover it with the included light-protective case (light has a destructive effect on thioctic acid). A solution is prepared from the concentrate: the contents of one ampoule are mixed with 50-250 ml of 0.9% sodium chloride solution. It is recommended to administer the drug immediately, the maximum storage period is 6 hours.

Thiogamma tablets

The tablets are taken once a day before meals at the dosage prescribed by the doctor; the tablets are not chewed and washed down with a small amount of liquid. The duration of the course of therapy is 30-60 days and depends on the severity of the disease. It is permissible to repeat the course of therapy two to three times during the year.

Thiogamma for IVs

When using the drug, it is important to remember to use a light-protective case after removing the bottle from the box. The infusion must be carried out at an injection rate of 1.7 ml per minute. When administered intravenously, it is necessary to maintain a slow pace (period of 30 minutes), a dosage of 600 mg per day. The course of treatment is two to four weeks, after which it is possible to continue taking the drug in oral tablet form at the same daily dosage of 600 mg.

For facial skin

The drug Thiogamma has found its application for facial care. For this purpose, the contents of dropper bottles are used. The use of this form is due to the optimal concentration of the drug. The drug in ampoules is not suitable due to the high density of the active substance, this can cause an allergic reaction. The solution from the bottles must be applied twice a day - morning and evening. Before use, you need to wash your face with warm water (possibly with lotion) to soften the pores and deep penetration of the active ingredient.

Special instructions

Among the sections of the instructions for use, the special instructions paragraph deserves close study. It contains rules and recommendations for using the drug:

1. The medication is prohibited for use by patients with fructose intolerance, glucose-galactose malabsorption syndrome, and glucose-isomaltase deficiency.
2. In case of diabetes mellitus, at the beginning of therapy, blood glucose levels should be carefully monitored; sometimes dose adjustment of insulin and other hypoglycemic agents is required. One tablet contains less than 0.0041 bread units.
3. During treatment you should refrain from drinking alcohol. This reduces the therapeutic effect and may cause progression of neuropathy.
4. During treatment, you can operate dangerous machinery and vehicles. The drug does not impair concentration and clarity of vision.

During pregnancy

Due to the content of active substances, the use of Thiogamma during pregnancy and lactation is prohibited. This is associated with a high risk of disruption of the vital functions of the fetus and the development of the infant or newborn. If it is impossible to stop using the drug during lactation, then it is necessary to stop or stop breastfeeding to avoid harm to the baby.

In childhood

The drug is prohibited for use by people under 18 years of age. This is due to the increased effect of thioctic acid on metabolism, which can lead to uncontrollable consequences in the body in children and adolescents. Before use, you should definitely consult a doctor and obtain permission after a thorough examination of your organs and systems.

Thiogamma for weight loss

Lipoic acid is an antioxidant, accelerates metabolic processes, improves the functioning of the pancreas, so it can be used for weight loss. It regulates sugar levels, slows down the aging process, improves blood flow, accelerates the process of converting carbohydrates into energy, and promotes the oxidation of fatty acids. The acid also blocks an enzyme in brain cells that is responsible for sending hunger signals, which helps control appetite.

As we age, the production of lipoic acid slows down, so it is used as a continuous supplement. The drug Tiogamma can be used for weight loss, but subject to regular physical activity. Nutritionists advise taking 600 mg of the active ingredient/day before or after breakfast, along with carbohydrates, after training or with the last meal. At the same time as taking it, you should reduce the caloric content of food consumed.

Drug interactions

Thioctic acid in Thiogamma enhances the anti-inflammatory effect of glucocorticosteroids. Other examples of drug interactions:

1. The drug reduces the effectiveness of Cisplatin.
2. The active substance binds metals, so the simultaneous use of iron, calcium and magnesium supplements is prohibited - at least two hours must pass between the use of these drugs.
3. The medication enhances the effect of insulin and oral hypoglycemic agents.
4. Ethanol and metabolites weaken the effect of the acid.

Side effects

While taking Thiogamma, various side effects may occur. The most common ones include:

1. nausea, diarrhea, vomiting, stomach pain, hepatitis, gastritis;
2. intracranial hemorrhage;
3. respiratory disorders, shortness of breath;
4. allergic reactions, anaphylactic shock, skin rash, itching, urticaria;
5. disturbance of taste sensations;
6. decreased concentration of glucose in the blood - hypoglycemia: dizziness, headache, increased sweating, blurred vision.

Overdose

Symptoms of an overdose of Thiogamma are headache, vomiting, nausea. Acute overdose is manifested by confusion, psychomotor agitation, generalized convulsions, and the formation of lactic acidosis. Sometimes shock, hemolysis, intravascular coagulation, and bone marrow suppression may occur. Taking 10-40 g of thioctic acid in combination with alcohol leads to multiple organ failure, intoxication, and death. There is no specific antidote; symptomatic therapy, analgesics, and injections are prescribed.

Contraindications

The drug is not prescribed during pregnancy, breastfeeding, children and adolescents under 18 years of age. Other contraindications for the use of the drug Tiogamma are:

1. galactose intolerance;
2. hepatitis, cirrhosis;
3. epileptic seizures;
4. lactase deficiency;
5. glucose-galactose malabsorption;
6. hypersensitivity to the components of the composition or thioctic acid.

Terms of sale and storage

You can buy the drug Thiogamma with a prescription; it should be stored in a dry place, inaccessible to children, at a temperature of up to 25 degrees for no more than five years.

Analogues of Thiogamma

Thiogamma substitutes include those drugs that contain the same active substance. Analogues of the drug:

1. Lipoic acid is a tablet preparation, a direct analogue;
2. Berlition – tablets and concentrated solution based on thioctic acid;
3. Thiolepta - plates and solution for the treatment of diabetic, alcoholic neuropathy;
4. Thioctacid turbo is a metabolic drug based on alpha-lipoic acid.

The cost of purchasing Thiogamma will depend on the chosen form of release of the drug, the amount of medicine in the package and the pricing policy of the retailer and manufacturer. Approximate prices for the product in Moscow:

Solution for infusion 150 ml

Tablets 600 mg, 30 pcs.

Tablets 600 mg, 60 pcs.

Solution for infusion 50 ml, 10 bottles

Reviews

Alla, 37 years old The drug Tiogamma was recommended to me by a friend who lost weight on it beyond recognition. She took it with the doctor’s permission, after training, and additionally restricted herself in nutrition. I started taking pills and eating right, and lost five kilograms in a month. Excellent result, I think I will repeat the course more than once.

Alexey, 42 years old Due to my addiction to alcohol, I developed polyneuropathy, my hands were shaking, and I began to suffer from frequent mood swings. Doctors said that we must first recover from alcoholism, and then eliminate the consequences. At the second stage of therapy, I began taking Thiogamma solution. It effectively copes with the problem of neuropathy, I began to sleep better.

Olga, 56 years old I suffer from diabetes, so I have a tendency to develop neuropathy. Doctors prescribed the drug Thiogamma for prevention, and additionally adjusted the insulin dose. I take the pills according to the instructions and see changes - I have become much calmer, I no longer have cramps at night and in the morning, my hands do not shake from anxiety.

Larisa, 33 years old I heard advice from a friend in cosmetology: use lipoic acid in ampoules to eliminate age spots and incipient wrinkles. I asked the doctor to write out a prescription and bought it and used it in the evenings: after washing my face, I applied the solution instead of tonic, and then the cream on top. Within a month, the spots began to disappear, the skin became noticeably fresher.

The drug Thiogamma is involved in the metabolic processes of the human body, as described in the instructions for use. By following step-by-step recipes for preparing facial care products, you can get a rejuvenating effect.

Release forms and price

The drug Thiogamma is available in two forms:

1. Thiogamma-Turbo solution for intravenous drip infusions:

1. 50 ml – 1.2% of the main substance;
2. the solution is packaged in a glass bottle with a metal cap;
3. the bottle is placed in a box made of thick paper;
4. the cost of the drug ranges from 200 rubles. up to 260 rub.

Thiogamma-Turbo solution for intravenous drip infusions:

1. 20 ml – 3% of the main substance;
2. the product is available in ampoule packaging;
3. in a box made of thick paper – 5 pcs;
4. the price of the solution varies from 500 rubles. up to 560 rub.
   
   
   
   

2. Tablet form of Thiogamma:

1. drug for oral use;
2. 1 tablet – 600 mg, has a dry dense coating;
3. in one plate there are 10 tablets;
4. in a box of thick paper, 3 plates and 6 plates;
5. the price for a tablet drug ranges from 870 rubles. up to 1600 rub.

Compound

All forms of the drug Thiogamma contain the organosulfur compound thioctocid:

1. Thiogamma-Turbo:

1. the main component in 50 ml is 0.6 g of thioctocide;
2. medical liquid;
3. ethylene glycol polymer.

2. Thiogamma-Turbo in ampoules:

1. the main component in 20 ml is 0.6 g of thioctocide;
2. medical water;
3. polyethylene glycol.

3. Tablet form of Thiogamma:

1. main substance in 1 tablet. – 0.6 g thioctocide;
2. silicon oxide;
3. natural polymer;
4. fatty powder;
5. milk carbohydrate;
6. methylhydroxypropylcellulose.

Medical purpose of the drug

Thiogamma (the instructions for use provide detailed information about the purpose of the drug) is used for diabetic disorders of the sensitivity of the skin, polyneuropathy.

The organosulfur compound thioctocid controls the metabolic processes of carbon hydrate and triacyglycerides, has a good effect on the metabolic process of polycyclic lipophilic alcohol, protects the liver, improves the performance of liver enzymes, and has a restorative capacity for tissues and internal organs of the body.

The effect of the organosulfur compound thioctocid on the human body has a restorative effect on cellular metabolism.

Benefits for facial skin

Thiogamma (the instructions for use do not describe the benefits of the drug in cosmetology) can benefit the skin of the face when used correctly.

Benefit:

1. the use of the drug inhibits the destruction of alpha helices;
2. promotes a process that prevents sugar and protein molecules from sticking together, which manifests itself in the form of a reduction in wrinkles;
3. restores the strength, softness and flexibility of the skin;
4. helps in the process of cellular regeneration;
5. promotes exfoliation of dead cells of the upper stratum corneum of the skin;
6. accelerates the formation of young epidermal cells;
7. frees facial pores from stagnation;
8. relieves inflammatory processes in the epidermis;
9. improves microcirculation in the skin.

Contraindications in cosmetology

The instructions for use of the drug Tiogamma do not describe contraindications related to cosmetology.

But it is important to consider that any medicine has limitations in use:

1. intolerance to the main substance of the drug – the organosulfur compound thioctocid, which is a fairly strong allergic agent;
2. age of children under 12 years old;
3. pregnancy;
4. lactation period;
5. renal failure;
6. liver pathologies;

According to the instructions for use, Thiogamma is prohibited during exacerbations of hepatitis A

Possible side effects

Tiagamma (instructions for use describe the undesirable effects of the drug due to improper use or personal intolerance) – medicinal a drug whose use may cause side effects:

1. in some cases, painful muscle spasms may occur;
2. taste disturbance;
3. dissociated hypogeusia;
4. allergic vasculitis;
5. hemorrhagic rashes;
6. inflammation of the venous walls with accumulation of blood clots;
7. Quincke's edema;
8. anaphylaxis;
9. the appearance of eczematous itchy ulcers;
10. nettle rash at the site of Tiagamma application;
11. allergic dermatitis;
12. digestive disorders with loose stools;
13. severe insufficiency of pulmonary ventilation;
14. intracranial hypertension;
15. drop in serum glucose levels;
16. feeling of heat in the body;
17. loss of balance;
18. hyperhidrosis;
    
    
    
    
19. nausea;
20. double vision;
21. disturbance of heart rhythm in the direction of increasing heart rate;
22. migraine headaches;

Using tablets for the face

The active use of Thiogamma tablets is observed among those who want to have tightened facial skin. Although the drug was originally intended by the pharmaceutical industry for other purposes.

Recipes for anti-aging home remedies with Thiogamma tablets:

1. Mask for the care of aging skin with the organosulfur compound thioctocid:

1. you need to purchase Thiogamma in tablets, Acetylsalicylic acid in tablets and sea salt at the pharmacy;
2. Lightly grind the salt in a coffee grinder until it is finely ground;
3. sea ​​salt must be slightly moistened with water, it is better if it is a prematurely prepared decoction of chamomile;
4. Apply the resulting product to all folds on the face, lightly pressing in with massage movements;
5. it is necessary to make a mixture of Thiogamma and Acetylsalicylic acid tablets;
6. the resulting fine powder should be applied over the sea salt, lightly rubbing in with gentle massage movements so as not to damage the skin;
7. After a couple of minutes, the scrub mask should be washed off the face using a suitable cleanser for your skin type;
8. for enlarged pores, the skin can be wiped with a piece of pre-prepared ice;
9. for dry skin, apply moisturizer;
10. a combination mask with Thiogamma should be used no more than once every 14 days.

2. Mask with Tiogamma against shine on the face:

1. you should take 1 tablet of the drug Tiogamma, 1 tbsp. l. honey melted in a steam bath, unrefined extra virgin olive oil or flaxseed oil - 1 tbsp. l. and 1 tbsp. l. juice of a three-year-old aloe plant;
   
   
   
   
2. the tablet must be ground into a fine powder and combined with all components;
3. Apply the resulting composition to a cleansed and steamed face;
4. duration of the procedure – 30 minutes;
5. to get the effect of therapy, you need to do the mask 3 times a week;
6. In total, up to 14 procedures should be done.

3. Mask using Thiogamma for dry skin:

1. you need to take 40 g of everyday facial moisturizer and heat it a little in a steam bath;
2. Grind 2 tablets of the drug Thiogamma into powder;
3. take 15 ml of pharmaceutical rose oil and mix all the ingredients thoroughly;
4. Add 3 drops of retinol and tocopherol to the resulting mixture;
5. apply the product to prematurely cleansed facial skin;
   
   
   
   
6. Duration of the procedure is up to 30 minutes;
7. You should make combined masks with Thiogamma no more than 2 times a week.

4. Combined recipe with Tiogamma tablets for rejuvenation:

1. you should take 6 Thiogamma tablets and crush them into powder;
2. the resulting medicinal powder must be dissolved in salicylic alcohol - 2 tbsp. l.;
3. add 4 ml of Caffeine-Sodium Benzoate to the product made from tablets and salicylic alcohol and mix thoroughly;
   
   
   
   
4. Apply the resulting mask to a previously cleansed face for 30-40 minutes;
5. Next, the product should be washed off and lubricated with a moisturizer;
6. The procedure must be done once every 7 days.

Application of the solution

Tiagamma (the instructions for use of the product do not describe the cosmetic use of the drug in cosmetology) in the form of a solution for intravenous drip injections is used in the form of lotions and tonic, in different versions.

Recipe and method of use:

1. For quick facial skin rejuvenation:

1. you should take 50 ml of Thiogamma solution;
2. you need to add 10 drops of tocopherol to the medicine;
3. shake thoroughly;
4. Wipe your face with the resulting product at night (on cleansed skin);
5. The procedure should be done daily for at least 1 month;
6. the result will be visible after the first procedures;
7. the product can be stored in the refrigerator for no more than 14 days;
8. The mixture must be shaken before use.

2. Lotion with Thiogamma solution:

1. take the drug Thiogamma for injection in a volume of 50 ml;
   
   
   
   
2. mix the liquid with a bottle of Retinol acetate purchased at the pharmacy;
3. the resulting lotion should be poured into a colored glass bottle;
4. It is recommended to wipe your face with the product in the morning and at night;
5. the lotion can be used as a base for makeup;
6. use the product for a month and take a break for 3 months;
7. repeat courses if necessary;
8. The lotion should be stored in the refrigerator for no more than 1 month.

3. Wiping the face with pure Thiogamma medicinal solution:

1. take a bottle of Thiogamma 50 ml;
2. cleanse your face before going to bed;
3. take a cotton swab and moisten it with a solution of the drug Thiogamma;
4. Apply the product to the skin with gentle movements along the lines of the face;
5. It should be remembered that the drug Thiogamma in undiluted form can provoke an allergic reaction, so you should definitely do a test by spreading the product on the back of your hand before use and wait about 30 minutes;
6. if there are no negative manifestations, you can use the drug;
7. The product should not be washed off;
8. on top of the dried Thiogamma you need to apply a night cream suitable for your skin type;
9. This procedure should be done within 1 month – 2 times a year.

Analogues of the drug

The pharmacological industry produces a large number of drugs with scientifically proven biological, pharmaceutical, and clinical similarities to the drug Thiogamma:

1. Octolipen tablets and capsules:

1. The composition of the tablet preparation includes cyclic disulfide carboxylic acid, cellulose base, hypuric acid, disintegrant, silicon oxide, stearic acid with magnesium, opadry coating, methyloxypropylcellulose, ethylene glycol polymer, titanium white, silicate fatty powder, synthetic azo dye, a compound of iron and oxygen;
   
   
   
   
2. the capsule form of the drug Thiogamma contains: fatty thioctic acid, calcium phosphate, mealy corn carbohydrate, polysorb, stearic acid with magnesium salt, titanium dioxide, yellow-green dye, food coloring, lemon-colored dye, collagen with antiseptic;
3. both forms of the drug have a protective function regarding plasma membranes, stimulating the production of new liver cells, reduces the level of bad polycyclic alcohol, has an anti-atherosclerotic effect, restores normal blood glucose levels, restores nutrition to nerve tissue, and helps remove excess glucose from the body.

2. Lipoic acid – injection solution:

1. the composition of the product includes a natural organosulfur compound of carboxylic acid, diaminoethane, Trilon B, sodium salt of hydrochloric acid, medical water;
2. the drug has a positive effect on metabolic cellular processes and the body as a whole. Participates in the development of carbohydrate and triglyceride metabolism, helps normalize the amount of lipids and bad polycyclic alcohol, reduces the saturation of the liver with fat, binds and accelerates the elimination of harmful substances in the body.

3. Berlition 300 units – drug for injection:

1. the composition of the medicinal liquid includes an organosulfur compound of lipoic acid, ethylenediamine, a fatty organic compound, a medical liquid;
   
   
   
   
2. the drug functions as coenzymes, which accelerate many chemical reactions in the human body: relieves inflammation, has a decongestant effect, is an immunostimulant, improves capillary circulation, has the property of restoring the functions of damaged tissues and organs, and improves supply to nerve cells.

4. Alpha lipon – tablet preparation:

1. one tablet contains 0.3 g or 0.6 g of thioctocide, milk sugar, natural polymer, sodium carboxyl methylcellulose, mealy corn carbohydrate, sodium dodecyl sulfate, silicon dioxide, stearic acid with magnesium, gel polymer, indtgocarmine, sulfonated food coloring, dioxide titanium;
2. the drug has a restorative effect on flat cells of lymphatic and blood vessels. Which, in turn, expand and cleanse the affected arteries and veins from products of high sugar levels in the body and in the cardiovascular system. They help the local nervous system, reducing vascular hyperemia. They improve microcirculation in liver cells, which contributes to better functioning of the organ as the main filter of the body.

5. Dialipon in capsules:

1. the drug contains an enantiomer of enzymatic complexes 0.3 g, milk disaccharide, natural polymer, methylhydroxypropylcellulose, silicon oxide, stearic acid with magnesium;
   
   
   
   
2. the drug restores the vital activity of nerve cells in the peripheral system by improving the functioning of blood vessels. Helps relieve swelling, improves oxygen supply to tissues and organs of the body, and restores sensitivity in the limbs. Reduces pain that results from damaged blood vessels and nerve endings due to improper production of the hormone insulin. It is a drug that should be taken to prevent the negative effects of high blood sugar.

Results and reviews from cosmetologists

Any pharmacological drug is tested by time. From the reviews of cosmetologists, the conclusion is formed that the drug is not a panacea for age-related skin changes; if used incorrectly, it can cause harm to the body in the form of local allergic reactions.

The main pharmacological feature of the drug is aimed at treating the disease - diabetic polyneuropathy, and not wrinkles.

But the drug has also found application in cosmetology - dermatologists-cosmetologists note that constant, systematic, correct use of Tiogamma can help improve the external condition of facial skin, works with fine wrinkles - slows down the natural process of age-related changes.

Thiogamma tablets and solution are a medicine that the instructions for use describe as a strong antioxidant. By using the drug in the correct proportions, you can help your facial skin stay young and beautiful longer.

Article format: Mila Friedan

Video about the drug Thiogamma

Is thiogamma really effective for the face?

Prices in online pharmacies:

Thiogamma is a drug with antioxidant and metabolic effects; regulates carbohydrate and lipid metabolism.

Release form and composition

Thiogamma is available in the following forms:

1. film-coated tablets: biconvex, oblong, light yellow with white or yellow inclusions of varying intensity, there are marks on both sides; the cut shows a light yellow kernel (10 pieces in blisters, 3, 6 or 10 blisters in a cardboard pack);
2. solution for infusion: transparent, yellowish-green or light yellow liquid (50 ml in dark glass bottles, 1 or 10 bottles in a cardboard box);
3. concentrate for preparing a solution for infusion: transparent yellowish-green liquid (20 ml in dark glass ampoules, 5 ampoules in cardboard trays, 1, 2 or 4 trays in a cardboard pack).

1 tablet contains:

1. active ingredient: thioctic (alpha-lipoic) acid – 600 mg;
2. auxiliary components: microcrystalline cellulose, croscarmellose sodium, simethicone, colloidal silicon dioxide, lactose monohydrate, talc, magnesium stearate, hypromellose;
3. shell: talc, macrogol 6000, sodium lauryl sulfate, hypromellose.

1 ml of solution for infusion contains:

1. active ingredient: thioctic (alpha-lipoic) acid – 12 mg (per 1 bottle – 600 mg);
2. auxiliary components: macrogol 300, meglumine (to correct the pH value), water for injection.

1 ml of concentrate for the preparation of solution for infusion contains:

1. active ingredient: thioctic acid – 30 mg (per 1 ampoule – 600 mg);
2. auxiliary components: macrogol 300, meglumine (to correct the pH value), water for injection.

Indications for use

The drug Thiogamma is used to treat alcoholic and diabetic polyneuropathy.

Contraindications

1. children and adolescents up to 18 years of age;
2. pregnancy period;
3. breastfeeding period;
4. glucose-galactose malabsorption, lactase deficiency, hereditary galactose intolerance (for tablets);
5. hypersensitivity to the main or auxiliary ingredients of the drug.

Directions for use and dosage

Film-coated tablets

The drug Thiogamma in tablet form is taken orally, on an empty stomach, with a small amount of liquid.

Recommended dose – 1 pc. (600 mg) once a day. The duration of therapy depends on the severity of the disease and ranges from 30 to 60 days.

During the year, the course of treatment can be repeated 2-3 times.

Solution for infusion, concentrate for the preparation of solution for infusion

The drug Thiogamma in the form of a solution is administered intravenously slowly, at a rate of about 1.7 ml/min for 30 minutes.

The recommended daily dose is 600 mg (1 bottle of solution for infusion or 1 ampoule of concentrate for preparing an infusion solution). The drug is administered once a day for 2–4 weeks. After which the patient can be transferred to the oral form of Thiogamma in the same doses (600 mg per day).

The drug in the form of a solution for infusion is ready for use. After releasing the bottle from the box, it is immediately covered with a special light-protective case to prevent light from reaching the thioctic acid, which is sensitive to its effects. Intravenous infusion is performed directly from the bottle.

When using Thiogamma in the form of a concentrate, you must first prepare an infusion solution. To do this, the contents of one ampoule of concentrate are mixed with 50–250 ml of isotonic sodium chloride solution. The prepared solution is immediately covered with a light-protective case. The infusion solution is administered immediately after preparation. Its storage duration is no more than 6 hours.

Side effects

Film-coated tablets

1. digestive system: vomiting, nausea, diarrhea, abdominal pain;
2. central nervous system: change or disturbance of taste;
3. endocrine system: a decrease in the concentration of glucose in the blood and the resulting symptoms of hypoglycemia (headache, dizziness, visual disturbances, increased sweating);
4. allergic reactions: urticaria, itching, skin rash, systemic reactions (up to anaphylactic shock).

Solution for infusion

1. central nervous system: change or disturbance of taste, convulsions (up to epileptic seizures);
2. organ of vision: bifurcation of visible objects;
3. hematopoietic system: thrombocytopenia, thrombophlebitis, hemorrhagic rash, pinpoint hemorrhages in the skin and mucous membranes;
4. skin and subcutaneous tissue: eczema, itching, rash;
5. endocrine system: a decrease in the concentration of glucose in the blood and the resulting symptoms of hypoglycemia (headache, dizziness, visual disturbances, increased sweating);
6. allergic reactions: urticaria, systemic reactions in the form of nausea, itching and discomfort (up to anaphylactic shock);
7. reactions at the injection site: hyperemia, irritation or swelling;
8. other reactions: difficulty breathing and increased intracranial pressure (with rapid administration of the drug).

special instructions

In patients with diabetes, especially at the beginning of drug therapy, blood glucose levels should be monitored. If necessary, doses of oral hypoglycemic agents and insulin are adjusted.

If symptoms of hypoglycemia appear, Thiogamma should be discontinued immediately.

During the treatment period, it is necessary to refrain from drinking alcohol-containing drinks, since alcohol reduces the effectiveness of the drug and is a risk factor for the development and progression of neuropathy.

One 600 mg tablet contains less than 0.0041 XE (bread units).

Direct use of Thiogamma does not affect the patient’s ability to drive vehicles or operate other potentially dangerous mechanisms. But it is necessary to take into account possible side effects from the endocrine system, due to a decrease in blood glucose levels, such as visual disturbances and dizziness.

Drug interactions

When thioctic acid is used together with glucocorticosteroids, their anti-inflammatory effect is enhanced; with cisplatin – the effectiveness of cisplatin decreases; with insulin or oral hypoglycemic agents - their effect may be enhanced; with ethanol and its metabolites - the effectiveness of thioctic acid decreases.

Thiogamma binds metals, so the drug should not be used together with medications containing metals (for example, magnesium, iron, calcium). There should be an interval of at least 2 hours between taking thioctic acid and these drugs.

The solution for infusion should not be mixed with Ringer's solution, dextrose solution and solutions that react with SH groups and disulfide groups.

Terms and conditions of storage

Store in a dry place at a temperature not exceeding 25 °C. Keep away from children.

The shelf life of the drug is 5 years.

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