Triampur compositum
Country of origin: Germany
Pharm-Group: Combined diuretics
Manufacturers: Arzneimittelwerk Dresden GmbH (Germany)
International name: Hydrochlorothiazide + Triamterene
Synonyms: Apo-Triazide, Vero-Triamtezid, Dyazid, Triam-ko, Triamtezid, Triamtel
Dosage forms: tablets
Composition: 1 tablet contains hydrochlorothiazide 12.5 mg and triamterene 25 mg.
Indications for use: Arterial hypertension, edema syndrome of various origins (for chronic heart failure, liver and kidney diseases). Maintenance therapy in the treatment of heart failure with glycosides in patients with a tendency to edema.
Contraindications: Hypersensitivity (including to sulfonamides), renal failure, anuria, acute glomerulonephritis, severe liver dysfunction (precoma and hepatic coma), disorders of electrolyte metabolism that cannot be corrected: hypokalemia, hyperkalemia, hypercalcemia, hyponatremia; hypovolemia. Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.
Side effects: From the nervous system and sensory organs: sometimes - ataxia, drowsiness, dry mouth, thirst, fatigue, headache, nervousness; rarely - mild visual disturbances, worsening of existing myopia, decreased tear secretion, etc. From the cardiovascular system and blood (hematopoiesis, hemostasis): sometimes - ECG changes, palpitations, decreased blood pressure, orthostatic hypotension, changes in the blood picture, etc. side of the gastrointestinal tract: nausea, vomiting, diarrhea, sometimes - epigastric pain, adynamia of intestinal smooth muscles, partial intestinal obstruction; in some cases, jaundice, hemorrhagic pancreatitis, inflammation of the gallbladder (in the presence of cholelithiasis). From the metabolic side: disturbance of electrolyte balance, water metabolism, metabolic acidosis, increased levels of cholesterol, triglycerides, glucose, uric acid in the blood; dehydration, hypovolemia. From the musculoskeletal system: skeletal muscle flaccidity, muscle tension, cramps of the calf muscles. Allergic reactions: in rare cases - redness and itching of the skin, urticaria, erythematosis, exanthema, fever.
Interaction: Antihypertensive drugs (especially ACE inhibitors), diuretics, barbiturates, phenothiazines, tricyclic antidepressants, vasodilators enhance the hypotensive effect; NSAIDs weaken. Indomethacin, when used simultaneously, reduces glomerular filtration, cholestyramine reduces absorption, potassium salts, potassium-sparing diuretics, ACE inhibitors increase the risk of hyperkalemia, glucocorticoids and laxatives - hypokalemia. Weakens the effect of antidiabetic, antigout drugs, norepinephrine and adrenaline, enhances the cardio- and neurotoxic effects of lithium, the side effects of salicylates on the central nervous system; enhances the effect of curare-like muscle relaxants, cardiac glycosides (in the presence of potassium and/or magnesium deficiency in the body), cytostatics (on the bone marrow); reduces the excretion of quinidine.
Overdose: No data available.
Special instructions: No data available.
Literature: Encyclopedia of Medicines 2003