Warthin-Finkelday Cells

Warthin-Finkelday cells are cells that are formed as a result of an inflammatory process in the salivary glands and can be detected in the diagnosis of oral diseases such as sialadenitis (inflammation of the salivary glands) or cancer of the salivary glands.

Warthin-Finkeldei cells are round in shape and are found in the oral cavity. They may be yellow or white in color and are surrounded by histiocytes, which are immune system cells responsible for killing infection.

With sialadenitis, these cells can increase in number and occupy most of the oral cavity. If this occurs in cancer of the salivary glands, then Warthin-Finkeldei cells can be replaced by cancer cells.

To diagnose oral diseases, it is important to analyze the cells that are found in saliva. In this case, Warthin-Finkelday cells can be detected, which makes it possible to determine the presence of infection or cancer.

Warthin-Finkelday cells are pathological structures found in the tissues of various organs during inflammatory and infectious diseases. They are accumulations of inflammatory cells, mainly macrophages, which are characterized by changes in shape and size.

The discovery of this type of cell is associated with the names of two famous pathologists - American scientists Warthin (Whitaker Alston Warthin, 12/07/1865-11/03/1940) and German pathologist Finkeldei (Wendelt Finkeldei, 04/27/1899-06/22/1975). In 1913, they published their first descriptions of these structures in a paper entitled "A New Type of Pathological Cell."

Warthina and Finkelday identified cells based on morphological characteristics, including the shape and size of macrophages. These cells have a round or oval nucleus and a cytoplasm containing characteristic inclusions (granules). The size of these cells can vary from a few microns to several millimeters.

The morphological features of Warthin-Finkelday cells often resemble cancer cells, but in fact they are normal cells that have undergone degenerative changes under the influence of infections, tumors, metabolic disorders and other factors. It is important to note that the accumulation of these cells in tissues is not synonymous with cancer, and the presence of Warthin-Finkelday cells does not indicate its presence.

Warthin-Finkelday cell accumulation factors can be associated with a wide range of pathologies, such as tuberculosis, syphilis, rheumatoid arthritis, viral infections, bacterial infections and many others.

Overall, Warthin-Finkeldei cells are a valuable morphological tool for pathologists, as they help determine the condition of tissue, inflammation and infection. An important aspect of their study is the study of the expression of various genes of these cells, which makes it possible to identify microarrays and mutations associated with their ability to multiply and divide.