**Waldenström Macrogobulinemia is** a rare lymphoproliferative disease in which plasma cells lose control of immunoglobulin synthesis. Currently, the disease is included in the group of chronic lymphoproliferative diseases, so it is possible to treat the disease using targeted therapy. Despite the fact that the disease is quite rare, it does exist in our medicine; it just needs to be identified in the early stages. Diagnosis and treatment of this disease are possible thanks to highly developed laboratory diagnostics, where specific antigens and substances can be detected. Sometimes you need