Wallerian Rebirth

Wallerian rebirth: a new look at an old phenomenon

Wallerian degeneration, or secondary degeneration of nerve fibers, was described in 1866 by the English physician August Waller. This phenomenon is that when a peripheral nerve is damaged, the axon disintegrates distally, and then the myelin, which forms the sheath around the nerve fiber. In this case, macrophages and other cells are activated, which remove the remains of the degenerated fiber. As a result of this process, a colliquation necrosis zone is formed, which can then be replaced by connective tissue.

Despite the fact that Wallerian degeneration was described more than 150 years ago, scientists still continue to study this phenomenon and its mechanisms. Recently, thanks to new technologies and research methods, new data have been obtained about the process of degeneration of nerve fibers and possible ways to restore them.

One of the most interesting and promising areas of research is the use of stem cells to restore damaged nerve fibers. Various studies show that stem cells can differentiate into nerve cells and even myelin sheaths, opening the possibility of developing new treatments for nerve damage.

In addition, recent studies have also discovered that Wallerian degeneration may have a role in various pathological processes such as neurodegenerative diseases, inflammatory processes and cancers. This opens up new opportunities for a deeper understanding of these processes and the development of new treatments.

Thus, Wallerian degeneration, although an old phenomenon, continues to be a relevant topic for research and the development of new treatments. New technologies and research methods are allowing scientists to gain an ever-increasing understanding of the processes that occur during nerve fiber degeneration, and are opening up new opportunities for the development of innovative treatments for nerve damage and other pathological conditions.

* **Wallerian Degeneration** is a degenerative neurological process that affects peripheral nerves and can lead to disability and other serious consequences. The name comes from the English physician and researcher James Waller, who described this disease in the 19th century.

* This condition is a form of inflammatory diseases of the central nervous system or demyelinating disorders. It includes several different forms, including postherpetic polyradiculopathy, Ellens-Danlos syndrome, Melkerson-Rosenthal syndrome, and others. Treatment