Vasoprene

Country of origin - Bulgaria
Pharm-Group - Antihypertensives - angiotensin-converting enzyme inhibitors

Manufacturers - Farmakhim-Sopharma (Bulgaria)
International name - Enalapril
Synonyms - Apo-Enalapril, Berlipril 10, Berlipril 20, Berlipril 5, Vasolapril, Vero-Enalapril, Invoril, Calpiren, Lerin, Miopril, Olivine, Renipril, Renitek, Ednit, Enazil 10, Enalacor, Enalapril, Enalapril ICN, Enalapril Hexal, Enalapril-Agio, Enalapril-Acri, Ena
Dosage forms - 5 mg tablets, 10 mg tablets, 20 mg tablets
Composition - Enalapril
Indications for use - Hypertension, symptomatic arterial hypertension, heart failure, diabetic nephropathy, secondary hyperaldosteronism, Raynaud's disease, scleroderma, complex therapy of myocardial infarction, angina pectoris, chronic renal failure
Contraindications - Hypersensitivity, pregnancy, breastfeeding, childhood
Side effects - CNS depression, depression, ataxia, convulsions, drowsiness or insomnia, peripheral neuropathy, visual impairment, taste, smell, tinnitus, conjunctivitis, lacrimation, hypotension, myocardial infarction, acute cerebrovascular accident (as a consequence of hypotension), violation heart rhythm (atrial tachy- or bradycardia, atrial fibrillation), orthostatic hypotension, angina attack, thromboembolism of the branches of the pulmonary artery, bronchospasm, dyspnea, nonproductive cough, interstitial pneumonitis, bronchitis and other upper respiratory tract infections, rhinorrhea, stomatitis, xerostomia, glossitis , anorexia, dyspepsia, melena, constipation, pancreatitis, liver dysfunction (cholestatic hepatitis, hepatocellular necrosis), kidney dysfunction, oliguria, urinary tract infections, gynecomastia, impotence, neutropenia, thrombocytopenia, exfoliative dermatitis, toxic epidermal necrolysis, pemphigus, herpes zoster , alopecia, photodermatitis, allergic reactions (Stevens-Johnson syndrome, urticaria, Quincke's edema, anaphylactic shock, etc.)
Interaction - The effects of enalapril are increased by diuretics, antihypertensive drugs, and alcohol. Weaken by estogens, NSAIDs, sympathomimetics. Potassium-sparing diuretics and potassium-containing drugs increase the risk of developing hyperkalemia
Overdose - Symptoms: hypotension, development of myocardial infarction, acute cerebrovascular accident and thromboembolic complications against the background of a sharp decrease in blood pressure. Treatment: intravenous administration of isotonic sodium chloride solution and symptomatic therapy
Special instructions - Caution must be exercised when prescribing the drug to patients on a low-salt or salt-free diet. Before and during treatment, monitoring of blood pressure, renal function, the concentration of transaminases and alkaline phosphatase in the vascular bed is necessary (if their levels increase, treatment is canceled). Prescribe the drug with caution in case of impaired renal function (dose selection should be carried out under the control of enalapril in the blood, since the glomerular filtration rate is inversely proportional to its level in plasma)
Literature - Register of Medicines of Russia 2002, Register of Medicines of Russia 2002.