Venter

Country of origin: Russia, Krka Slovenia, Krka d.d. Slovenia
Pharm-Group: Astringents, coatings and antacids based on aluminum

Manufacturers: Akrikhin HFC (Russia), Krka (Slovenia), Krka d.d. (Slovenia)
International name: Sucralfate
Synonyms: Alsukral, Andapsin, Ankrusal, Keal, Sukrabest, Sucralfate-Ratiopharm, Sucralfate, Sucralfate suspension, Sucras, Sucrat, Sucrafil
Dosage forms: tablets 1g, granules, tablets 500mg, tablets 0.5g
Composition: Active ingredient - sucralfate.

Indications for use: Peptic ulcer of the stomach and duodenum (prevention and treatment), damage to the gastrointestinal mucosa caused by stress or taking NSAIDs (prevention and treatment), hyperacid gastritis, gastroesophageal reflux disease, hyperphosphatemia in patients with uremia on hemodialysis.

Contraindications: Hypersensitivity, dysphagia or gastrointestinal obstruction, gastrointestinal bleeding, renal failure, pregnancy, children (up to 4 years).

Side effects: Dyspepsia, constipation or diarrhea, pain (abdominal, back, headache), dizziness, drowsiness, dry mouth, nausea, skin rash and itching, urticaria.

Interaction: Reduces the absorption of fluoroquinolones (ciprofloxacin, norfloxacin, ofloxacin), tetracycline, theophylline, phenytoin. Increases (mutually) the toxicity of drugs containing aluminum (especially in patients with renal failure). Activity is reduced by antacids and histamine H2 receptor blockers.

Overdose: No data available.

Special instructions: In patients with renal failure, monitoring the level of serum aluminum and phosphates is necessary - the appearance of drowsiness and convulsions may indicate the toxic effects of aluminum. When used in combination, antacids should be administered 30 minutes before or 30 minutes after sucralfate. Administration through a nasogastric tube may result in the formation of a bezoar with other drugs or parenteral nutrition solutions (due to protein binding).

Literature: Encyclopedia of Medicines 2004