Vesanoid

skin damage from sunlight.

Vesanoid (international name - Tretinoin) is a representative of the group of retinoids (vitamin A) and is produced by Hoffmann-La Roche Ltd., released by R.P. Scherer GmbH (Germany). Dosage form - capsules of 10 mg of active substance.

Vesanoid is used for the treatment of acute promyelocytic leukemia in patients who have not previously been treated or with relapses refractory to standard chemotherapy regimens. It is also used topically for the treatment of acne vulgaris (including the formation of comedones, papules, pustules), confluent acne, Favre-Rakucho disease (nodular cystic elastosis of the skin with comedones).

Contraindications to the use of Vesanoid include hypersensitivity to the drug and pregnancy. It is also necessary to stop breastfeeding. Limitations to use include the lack of reliable contraception in women of childbearing age.

Vesanoid can cause a number of side effects, including headache, weakness, fatigue, changes in vision and hearing, depression, loss of appetite, nausea, vomiting, diarrhea/constipation, bleeding disorders, arterial hypo- or hypertension, heart failure, cough, nasal congestion , pharyngitis, respiratory failure, pneumonia, edema and weight loss. When applied topically, hyperemia, swelling, peeling, areas of hyper- or hypopigmentation and allergic contact dermatitis are possible. It is also possible to develop "retinoic acid syndrome", which manifests itself in the form of fever, shortness of breath, shortness of breath, acute respiratory distress syndrome, pulmonary infiltrates, hyperleukocytosis, hypotension, pleural effusion, renal, hepatic or multiple organ failure and death.

The interaction of Vesanoid with ketoconazole may lead to an increase in the concentration of the drug in plasma. There is no data on overdose.

Before starting treatment for leukemia, a cytogenetic study is necessary. Women of reproductive age are recommended to use at least 2 types of contraception a month before, during and a month after the course. If there is a significant increase in the number of leukocytes in the blood, regular monitoring of leukocyte levels is recommended for prevention, as this may be associated with the risk of developing “leukocyte dissection” syndrome.

When treating skin diseases, Vesanoid is used topically, applying the product to the affected areas of the skin once a day, usually before bedtime. The duration of the course is determined by the doctor and can vary from several weeks to several months.

In general, Vesanoid is a serious drug that requires strict adherence to the recommendations and supervision of a doctor. It is necessary to evaluate the benefits of its use in relation to possible risks and side effects.