Von Willebrand's disease

Von Willebrand disease, also known as von Willebrand-Jund disease, is one of the most common inherited blood clotting disorders. The disease was named after the Finnish physician Erik Adolf von Willebrand, who was the first to describe its symptoms in 1926.

Von Willebrand disease is caused by dysfunction of the von Willebrand blood clotting factor, which plays an important role in the formation of platelet plugs when blood vessels are damaged. If the level or function of this factor is impaired, bleeding increases, which can lead to nosebleeds, bleeding gums, hemorrhages in the joints and muscles, and severe bleeding from injury or surgery.

Von Willebrand disease is inherited according to the principle of autosomal dominant genetic inheritance. This means that the risk of developing this disease in children of one of the carrier parents is 50%.

Diagnosis of von Willebrand disease includes measuring the level of von Willebrand factor in the blood and its functional activity, as well as conducting a coagulogram. Treatment for this disease is aimed at increasing the level of von Willebrand factor in the blood. For this purpose, drugs containing von Willebrand factor or drugs that increase its level in the blood can be used.

In general, von Willebrand disease is not dangerous, but can lead to serious complications in some circumstances. Therefore, it is important to know about the presence of this disease in the family and carry out timely diagnosis and treatment to prevent possible complications.

Von Willebrand disease is a hereditary blood disease that is associated with a blood clotting disorder. It occurs due to a deficiency or dysfunction of the von Willebrand protein. This protein is a key component of the blood coagulation system and is responsible for its normal functioning.

The disease was first described in 1929 by Finnish physician Erik Willebrand, who named it after himself. Since then, many different forms of the disease have been identified, which can present in different ways. Some forms may be mild and not cause serious health problems, while others may lead to serious complications such as bleeding and hemorrhage.

Treatment of the disease depends on its form and severity. In some cases, blood transfusions or the use of drugs that stimulate the body's production of von Willebrand protein may be required. A special diet may also be recommended to help improve the functioning of the blood clotting system.

An important point is early diagnosis of the disease. To do this, you need to undergo regular medical examinations and blood tests. It is also important to monitor your health and consult a doctor if there are any changes in your health.