Acanthosis Nigricans Malignant

Acanthosis nigrica maligna (syn.: malignant black hairy) is a rare skin disease caused by increased proliferation of benign dark-colored cell granules in the stratum corneum. In this case, an uneven thickening of the stratum corneum occurs. The disease is chronic and relapsing. As a rule, the reasons for its development are not clear. The most likely cause is metabolic or neuroendocrine disorders. The mutation of melanocortin-1-alpha receptor, which converts interleukin-2 into melanocyte-stimulating hormone, leads to the development of hyperpigmentation of many areas of the body and, in particular, the vestibule of the vulva, the area of ​​the labia majora, the bottom of the saucer, the bottom of the scrotum, the buttock