Adenosine for wrinkles

The description is valid on 02.07.2015

1. Latin name: Adenosinum
2. ATX code: C01EB10
3. Chemical formula: C₁H₁₃N₅O₄
4. CAS code: 58-61-7

Chemical name

Chemical properties

Adenosine is nucleotide, which consists of adenine And ribose, which are connected beta-N9-clicosidic linkage.

In the human body, this substance is part of ATP (adenosine triphosphate), nucleic acids and various enzymes. Thus, the component plays an important role in chemistry. processes occurring in the body, transmission of energy and signals. During wakefulness, the concentration of Adenosine increases slightly. The gross formula of Adenosine is C10H13N5O4. Its molecular weight = 267.2 grams per mole.

Adenosine monophosphate takes part in the process of cell signal transmission. There are 4 types adenosine receptors, 7 of which ensure the transmission of impulses between cell membranes. Near normal, healthy cells, the concentration of this substance reaches 300 nM. If the cell is damaged, inflamed or subjected to ischemia, then this figure rapidly increases to 700-1200 nM. Thus, Adenosine protects cells from the effects of adverse factors.

The drug has the form of a white crystalline hygroscopic powder. After hydrolysis Adenosine is formed as a solution - a white or white liquid with a yellowish tint, pH value which is from 7 to 7.3. The substance is highly soluble in water and practically insoluble in alcohol.

Adenosine has a strong anti-inflammatory effect. The drug acts on 4 receptors that are associated with G protein. In experiments conducted on rats, patients diabetes mellitus, after taking Adenosine, wound healing occurs much faster.

When the substance is administered intravenously, it blocks the functioning of damaged segments of the arteries, and temporary heart block develops in atrioventricular node. Thus, the blockade is diagnosed coronary arteries, supraventricular tachycardia. The substance is classified as a class 5 antiarrhythmic drug.

Recently, Adenosine has been added to cosmetics. This component stimulates the production collagen And elastin in the upper layers of the epidermis, has cytoprotective action. Based on it, creams and masks are created to reduce age-related wrinkles and smooth out skin texture.

pharmachologic effect

Antiarrhythmic, metabolic, diagnostic.

Pharmacodynamics and pharmacokinetics

Adenosine phosphate – natural high energy compound. Its antiarrhythmic effect is based on its ability to suppress sinus node automaticity and block the conduction of nerve impulses along Purkinje fibers. The product expands coronary vessels (increases current potassium ions And blocks calcium, the smooth muscles of the vascular walls relax), is strong vasodilator in almost all vascular beds, except hepatic veins And afferent arterioles.

The substance is also used topically in ophthalmology at cataract.

After entering the body, the medicine turns into inosine And adenosine monophosphate. It is quickly eliminated from the systemic circulation by cellular uptake. Does not bind to blood plasma proteins. The substance has an extremely rapid half-life - less than 30 seconds in purified plasma. Adenosine is completely metabolized and converted into hypoxanthine, uric acid or xanthine.

The substance does not have mutagenic influence on the body, reduces fertility (in experiments on rats).

Indications for use

Adenosine-based drugs are prescribed:

1. for intravenous administration and cupping paroxysmal supraventricular tachycardia;
2. when conducting scintigraphy or two-dimensional echocardiography, as an auxiliary diagnostic tool;
3. for treatment cataracts V ophthalmology (locally).

Contraindications

1. if there are reactions hypersensitivityto Adenosine;
2. if the patient 2nd or 3rd degree AV blockand no artificial pacemaker;
3. at bronchial asthma;
4. at sick sinus syndromeor ventricular tachycardia.

The medicine is used with caution when sinus bradycardia, unstable angina, pericarditis, heart defects, hypovolemia.

Side effects

After injection of the drug, you may experience:

1. facial redness,bradycardia, pain in the chest, decreased blood pressure;
2. difficulty breathing, bronchospasm;
3. violation AV conduction;
4. dyspnea, diplopia;
5. headaches, nervousnessand dizziness;
6. discomfort in the limbs, especially in the hands;
7. metal taste in the mouth, nausea, increased sweating;
8. allergic reactions(rarely);
9. paresthesia;
10. unpleasant, painful sensations in the throat, lower jaw, neck.

Also during post-marketing studies the following were identified: atrial And ventricular arrhythmia, increase HELL, loss of pulse, sinus tachy- And bradycardia.

Very rarely appeared:

1. myocardial infarction (non-fatal), increased heart rate, severe HELL;
2. tremor, vision problems, cough;
3. drowsiness, stuffy ears and nose, scotoma, discomfort on the tongue.

When applied topically, systemic reactions usually do not occur. The most likely development is burning, discomfort and tingling in the eyes.

Adenosine, instructions for use (Method and dosage)

Depending on the desired effect and disease, different dosages and methods of administration are used.

For elimination arrhythmias adults are administered intravenously, quickly (1-2 seconds) 6 mg of the substance. If after 60-120 seconds there is no improvement in the patient’s condition, another 12 mg can be administered. If necessary, injections can be repeated.

As antiarrhythmic means for children the substance is administered intravenously as a bolus at the rate of 50 mcg per 1 kg of child weight. Repeated injections can be given after 120 seconds, increasing the dosage by 50 mcg per kg of weight.

The maximum single dose is 250 mcg per kg of weight.

As a diagnostic agent, intravenous or intraosseous administration of 6 mg of the drug is used. It is recommended to give the injection as close to the heart as possible. Often, after administration of Adenosine, an injection of an isotonic solution in a dosage of 5 or 10 ml may be required. An additional dose can be administered after 60-120 seconds.

The maximum single dose for an adult is 12 mg.

In patients with an increased risk of complications, treatment begins with minimal doses.

IN ophthalmology the medicine is used topically, in accordance with the recommendations of a specialist.

Overdose

Since the substance is quickly metabolized and removed from the systemic circulation, in case of an overdose, all unwanted reactions go away on their own within a few minutes. However, as competitive antagonists, can be used methylxanthines (caffeine, theophylline).

Interaction

Caution should be exercised when combining this substance with carbamazepine. Because antiepileptic drug may strengthen blockade of the heart muscle.

When combining the drug with dipyridamole It is recommended to reduce the dosage of the drug.

Methylxanthines, caffeine and adenosine weaken the effect of Adenosine. In this regard, it may be necessary to increase the dosage of the medication.

Caution should be exercised when administering the drug intravenously in combination with beta-blockers, CCBs, cardiac glycosides.

Terms of sale

Storage conditions

Adenosine-based medications should be stored in accordance with the recommendations on the packaging.

special instructions

It is recommended to strictly follow the instructions for use for a particular dosage form of this substance.

During pregnancy and lactation

In pregnant women, the drug should not cause any undesirable effects. However, due to the insufficient number of clinical trials, medication can be prescribed during pregnancy after consultation with a specialist. The substance is not excreted in breast milk, so it can be used during lactation.

Drugs containing (Analogs)

Adenocor

Reviews about Adenosine

There are few reviews about the use of this product. Most often, injections are performed in a hospital setting, under medical supervision. personnel. Adverse reactions occur with the frequency described above and usually pass quickly.

Adenosine price, where to buy

At the moment, it is difficult to indicate the approximate cost of drugs containing Adenosine as an active ingredient.

Education: Graduated from Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.

Experience: From 2003 to 2013, she worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

When using beauty products, do you wonder what ingredients are included in them? We will tell you about the active substances for the health and beauty of the skin of the face and body, hair and nails, which are part of many beauty products. Now you will know why they are needed and what results and actions you can get from them.

ADENOSINE (ADENOSINE)

Adenosine molecules are essential for regulating blood flow and providing energy to cells and are present in the cells of all living organisms.
Adenosine is one of the most advanced ingredients of the new generation. This component greatly increases the production of collagen and elastin in the skin, softens and tightens the skin, restores it after excess sunbathing and relaxes wrinkles.
That is why adenosine began to be actively used in skin care cosmetics for the face and body as one of the most effective anti-aging agents against wrinkles and smoothing skin texture, as well as slowing down the aging process. It also affects the synthesis of procollagen 1, which is responsible for skin elasticity and tone.
Adenosine does not lose its properties when exposed to heat and light, so cosmetic creams and serums containing it can be used both day and night.

Adenosine is also known for its strong anti-inflammatory and healing properties, and therefore is actively used in beauty products aimed at restoring the skin after various procedures.

We have selected the best professional beauty products that contain Adenosine:

Dermahil tonic is ideal for any skin, even sensitive and irritated, it provides gentle cleansing and ionization of the facial skin, and also moisturizes. Does not dry out the skin as it does not contain alcohol. It has several effects at once: rejuvenates, brightens and is an excellent antioxidant. Actively cleanses the facial skin of dirt, excess oil and gives the skin freshness and a feeling of cleanliness and hydration.

The main effect of the spray is highly intense hydration and restoration of facial skin. It is especially effective after laser procedures, as it reduces discomfort and discomfort, and also stops the development of erythema and swelling. The spray can be used instead of facial toner.

Cell Fusion C nanoemulsion can be used by any skin type. Ideal and indispensable for use after invasive procedures (IPL and fractional laser, dermabrasion and peeling). Cell Fusion C Endogen K is a highly effective antioxidant and anti-inflammatory agent, instantly and strongly moisturizes, and also prevents moisture loss, actively improves blood circulation, evens out skin tone and texture, and reduces the appearance of pigmentation.

Cell Fusion C extra restorative emulsion actively moisturizes and is an effective anti-inflammatory and soothing agent. After using the emulsion, the epidermal skin barrier is restored, and transepidermal moisture loss stops. Due to a complex of natural plant extracts, the Restoring Lipid Emulsion has a harmonizing effect on a woman's skin. Ideal for use on dry and normal facial skin.

Cell Fusion C Regenerating serum Ultimate Laser Rejuvenation Ampoule is a powerful rejuvenating agent. Due to its regenerating properties, the serum moisturizes and restores facial skin, has anti-inflammatory, immunomodulatory and antioxidant effects.

Intensive eyelid rejuvenation cream Dermaheal ULTRA AW 500 prevents dehydration and restores damaged skin around the eyes. Promotes highly intensive production of collagen, elastin, native hyaluronic acid, giving a pronounced lifting effect. Smoothes expression wrinkles and prevents their appearance.

After just one use of the Eye Filler Mask from Dermahil, there is a noticeable reduction in wrinkles by 40%, and after 3 weeks of use, the synthesis of collagen in tissues increases by 42%, elastin by 40%, and hyaluronic acid by 48%. Such results are obtained by transporting the active ingredients of the mask into the deep layers of the skin using nanoencapsulation. Nanocapsules are similar in structure to the skin cell membrane; they contain biomimetic Eye Filler Mask peptides. With the help of this structure, nanocapsules reach skin cells, passing through the stratum corneum. As a result, the mask achieves excellent results:
- fills, strengthens and tightens the skin
- smoothes out wrinkles
— provides 24-hour deep hydration of the skin of the eyelids
- Lightens hyperpigmentation and blue under-eyes
- reduces the severity of the nasolacrimal groove
- shrinks pores
- protects skin from premature aging

Sun protection factor 36 SPF. Has anti-inflammatory, soothing, antioxidant effects. Improves skin regeneration, including after invasive procedures. Prevents post-inflammatory pigmentation, has a brightening effect. Relieves erythema, tones, masks the skin

In the fight against old age, all means are good. But some are the best!

It's time to talk about the latest achievement of science, which created a sensation and, most likely, will leave cosmetologists working only with hyaluronic acid without work.

When do we talk about old age? Old age is not just numbers in a passport. This includes less elastic skin, decreased elasticity, and the appearance of wrinkles. Genetics, poor ecology, stress, chronic fatigue, vitamin deficiency and dozens of other factors accelerate the aging process. And even though it is inevitable, it can be slowed down, and with the right approach, reversed!

And the latest discovery by scientists - adenosine - will help preserve youth and beauty.

Adenosine – a sensation in biotechnology and cosmetology

Adenosine is a substance that is present in our DNA and is involved in many biochemical processes. In the human body, adenosine is synthesized independently, maintaining youth, strength and health.

This compound attracted the attention of cosmetologists with its ability to fight wrinkles. Scientists at the Massachusetts Medical School have proven that adenosine in cosmetics stimulates the synthesis of collagen and elastin, effectively smoothes wrinkles, reduces age-related changes and evens out skin texture.

Would you say that hyaluronic acid does the same thing? And you will not be entirely right!

Is adenosine more effective than hyaluronic acid?

Hyaluronic acid (HA) is a substance produced naturally by the body. HA consists of molecules that form a network with cells. This structure helps hyaluronic acid work like a super sponge - it attracts and holds water molecules in the cells. A gel is formed in which elastin and collagen fibers float - proteins responsible for the firmness and elasticity of the skin.

As in the case of adenosine, HA deficiency begins to be felt after 30-40 years. With age, the production of hyaluronic acid slows down, the skin becomes drier, loses turgor, and wrinkles appear. Therefore, scientists invented a synthetic analogue, which is widely used in cosmetology.

Despite all the benefits of hyaluronic acid, its application to the surface of the skin or injection does not affect the production of its own hyaluronic acid in the dermis. An important difference between cosmetic products with adenosine is that they help the skin produce its own collagen. Thanks to this action, they have become in demand all over the world.

Magic cosmetics with adenosine for rejuvenation

It has been proven that innovation provides:

1. Active synthesis of collagen and elastin in the skin.
2. Reducing the number of wrinkles and reducing their severity.
3. Leveling the surface of the skin.
4. Slowing down the processes of age-related skin changes.
5. Antioxidant effects (protection against oxidative stress).
6. Intensive skin restoration - wounds and cracks heal at an accelerated pace.
7. Anti-inflammatory effect.
8. Synthesis of procollagen-1, a substance that increases skin turgor and elasticity.

In other words, adenosine in cosmetology can replace many existing components, including hyaluronic acid.

The key difference between adenosine and HA is that innovative products have a multi-purpose effect on the skin. Adenosine comprehensively eliminates aesthetic imperfections of the skin and eliminates age-related changes. At the same time, it does not change its properties under the influence of light and temperature, so it can be used not only for injections, but also as part of day and night face creams.

Cosmetics with adenosine block skin aging and rejuvenate thanks to a unique mechanism of action. Without exaggeration, this is the best cosmetic ingredient in the fight against wrinkles.