Agglutination Microscopic

Agglutination (from the Latin agglutinatio - gluing) is a process in which blood cells stick to each other or to other surfaces. This can be caused by various reasons such as infections, allergies, autoimmune diseases and others.

Agglutination can be microscopic or macroscopic. Microscopic agglutination is a fine-grained agglutination that can only be detected under a microscope. It can be caused by various infectious agents such as bacteria, viruses, fungi and parasites.

Microscopic agglutination is one of the most common symptoms of infectious diseases. It appears in the form of small grains or flakes on the surface of the blood. These grains are formed due to red blood cells sticking to each other.

To diagnose infectious diseases caused by microscopic agglutination, special research methods are used, such as microscopy and blood culture in nutrient media. Enzyme immunoassay and PCR methods can also be used.

Treatment of infectious diseases associated with microscopic agglutination depends on the specific pathogen. In most cases, the use of antibiotics and antiviral drugs is required. Immunotherapy and symptomatic treatment may also be required.

Microscopic agglutination

An agglutination test is a research method used in medicine to identify specific antigens and antibodies in the blood of patients. The result of the analysis depends on the presence of protein or soluble immune complexes that form an agglutinogen. If the antibody is present, then flakes or threads of coaglutinate are formed on the surface of the aggluteninogen. The color of this mixture can vary from transparent to opaque gel. In medical tests, the determination of agglutination helps to identify the presence of various microorganisms, bacteria, antibodies, viruses and other particles in human and animal bodies.

**Uses** Determination of microscopic agglutinins is a common testing method for influenza virus infections, jaundice, typhoid fever, tetanus, diphtheria, hepatitis A, B, C, D and Creutzfeldt-Jakob disease. In addition, agglutination testing is used to differentiate between virulent and abortive strains. Can be used to determine the stability of clot formation, its shape and texture, and as an indicator of the activity of the enzyme agglutaminase, which breaks down formed clots.

The test procedure is carried out by adding antigens of bacterial or viral components to a sterile solution of the patient's blood. The mixture must be kept at room temperature for at least 30 minutes to form stable agglutins, then specialists study its structure using a light microscope or electron microscopy. The examination can be carried out manually, automatically or using a computer camera. An important point is the unambiguous interpretation of the result obtained, which requires appropriate qualifications and experience in applying these methods of analysis and conducting cross-reactions.

Microscopic agglutination allows you to obtain accurate results in the shortest possible time and is one of the most widely used laboratory research methods.