Aminomal

Country of origin - Italy
Pharm-Group - Bronchodilators - phosphodiesterase inhibitors

Manufacturers - A. Menarini (Italy)
International name - Aminophylline
Synonyms - Aminophylline, Diaphylline gluteusum, Pharmafillin, Eufillin, Eufillin for injection
Dosage forms - solution for intravenous injection 240 mg
Composition - A mixture consisting of 80% theophylline and 20% ethylenediamine.

Indications for use:

1. Chronic obstructive bronchitis
2. Bronchial asthma
3. Status asthmaticus (additional therapy)
4. Emphysema
5. Neonatal apnea
6. Cheyne-Stokes breathing

Contraindications:

1. Increased sensitivity
2. Acute gastritis
3. Peptic ulcer of the stomach and duodenum
4. Arrhythmia
5. Arterial hypertension
6. Myocardial pathology
7. Myocardial infarction
8. Heart failure
9. Prostate adenoma
10. Diarrhea
11. Cystic fibrous mastopathy
12. Alcoholism
13. Pulmonary heart
14. Fever
15. Hypoxemia
16. Respiratory tract infections
17. Liver dysfunction
18. Hyperthyroidism
19. Chronic and acute renal failure
20. Edema syndrome
21. Hypernatremia
22. Diseases of the rectum
23. Lactation

Side effect:

1. Heartburn
2. Vomit
3. Chest pain
4. Heartbeat
5. Hypotension
6. Headache
7. Dizziness
8. Feeling of blood rushing to the face
9. Tachypnea
10. Allergic reactions (sweating, fever)
11. Reactions at the injection site

Interaction:

1. Increases the likelihood of developing side effects of glucocorticoids, mineralocorticoids, anesthetics, xanthines and central nervous system stimulants, beta-adrenergic agonists.
2. Reduces the specific activity of lithium salts.
3. Oral contraceptives (estrogen-containing), antidiarrheal drugs, intestinal sorbents weaken, and H2-histamine blockers, fluoroquinolones, calcium channel blockers, beta-blockers, mexiletine, erythromycin enhance the effect of aminophylline.

Overdose:
Symptoms: nausea, vomiting, epigastric pain, gastrointestinal bleeding, anorexia, diarrhea, tachypnea, facial flushing, tachycardia, ventricular arrhythmias, insomnia, anxiety, photophobia, generalized convulsions.
Treatment: drug withdrawal, symptomatic therapy.

Special instructions: No data available.

Literature: Encyclopedia of Medicines 2004.