Antibodies Cytotoxic

Cytotoxic antibodies are a class of antibodies that can resist surface-located cellular antigens and cause irreversible damage to the cytoplasmic membrane of the target cell in the presence of complement.

Cytotoxic antibodies play an important role in the human immune system, protecting the body from infections and other harmful agents. They occur as a result of activation of the immune system upon contact with external agents such as bacteria, viruses or tumors.

One of the key mechanisms of action of cytotoxic antibodies is complement activation. Complement is a group of proteins that play an important role in the immune system by destroying infectious agents and other harmful particles. In the presence of complement, cytotoxic antibodies can form complexes with surface-located antigens on target cells. This leads to the activation of a cascade of complement reactions that cause irreversible damage to the cytoplasmic membrane of the target cell.

One example of Cytotoxic antibodies are antibodies against the Rh factor. These antibodies can occur in women who are Rh negative and are pregnant with a fetus that is Rh positive. In such cases, cytotoxic antibodies can cross the placenta and attack the red blood cells of the fetus, which can lead to hemolytic disease of the newborn.

In conclusion, it can be noted that cytotoxic antibodies are an important component of the human immune system, playing a role in protecting the body from infections and other harmful agents. However, in some cases, cytotoxic antibodies can cause unwanted effects such as hemolytic disease of the newborn. Therefore, the study of the mechanisms of action of Cytotoxic antibodies and the development of methods for their control are current areas of research in the field of immunology.

Antibodies Cytokinetic

**Cytotoxic type antibodies** are capable of causing cell destruction by destroying cytoplasmic structures and mitochondria when activated by complement. They have a fragmented mechanism of action - fusion with the components of the cell membrane occurs temporarily. Their viability is comparable to the duration of circulation in the bloodstream; this often contributes to the release of immune complexes from the bloodstream. They are characterized by the formation of IgG antibodies, which are characterized by the greatest antigenic activity. At the moment they are not used for the specific treatment of severe immune-related diseases. However, they have great prospects for use for research purposes in order to study the mechanisms of action and action of associated cytoreceptors, as well as for the development of methods for targeted therapy of malignant neoplasms with the participation of this type of immunocompetent cells.