Country of origin - Russia, ICN Marbiopharm Russia, Pharmstandard-Leksredstva Russia
Pharm-Group - Ascorbic acid group (vitamin C)
Manufacturers - AI CN Leksredstva (Russia), AI CN Marbiopharm (Russia), Pharmstandard-Leksredstva (Russia)
International name - Ascorbic acid
Synonyms - Additive Vitamin C, Ascorbic acid, Ascorbic acid, Ascorbic acid (Vitamin C), Ascorbic acid-UBF, Bartel drugs vitamin C, Bartel drugs vitamin C chewable with orange flavor, Vitamin C, Vitamin C "Dinosaurs", Vitamin C nat
Dosage forms - tablets 25 mg, chewable tablets 200 mg
Composition - Active ingredient - Ascorbic acid.
Indications for use - Hypovitaminosis C, hemorrhagic diathesis, capillary toxicosis, hemorrhagic stroke, bleeding (nasal, pulmonary, uterine, etc.), infectious diseases, intoxication, alcoholic and infectious delirium, acute radiation sickness, post-transfusion complications, liver diseases (Botkin's disease, chronic hepatitis and cirrhosis), gastrointestinal tract (achilya, peptic ulcer, especially after bleeding, enteritis, colitis, helminthiasis), cholecystitis, adrenal insufficiency (Addison's disease), sluggishly healing wounds, ulcers, bone fractures, dystrophy, physical and mental overload, pregnancy and lactation, hemosiderosis, melasma, erythroderma, psoriasis, chronic common dermatoses. As an antioxidant - atherosclerosis, bronchial asthma, diffuse connective tissue diseases (rheumatoid arthritis, systemic lupus erythematosus, scleroderma), etc.; overdose of anticoagulants, poisoning with aconite, anesthesin, aniline, antabuse, barbiturates, benzene, dichloroethane, potassium permanganate, methyl alcohol, arsenic, carbon monoxide, hydrocyanic acid, sulfonamides, thallium, phenols, quinine.
Contraindications - Hypersensitivity, thrombophlebitis, tendency to thrombosis, diabetes mellitus.
Side effect - Irritation of the gastrointestinal mucosa (nausea, vomiting, diarrhea), arterial hypertension, metabolic disorders, inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria) and glycogen synthesis, reduces capillary permeability and deterioration of tissue trophism, thrombocytosis, hyperprothrombinemia, thrombus formation, erythrocytopenia, neutrophilic leukocytosis, myocardial dystrophy, damage to the glomerular apparatus of the kidneys, allergic reactions (including anaphylactic shock); with long-term use, the formation of urinary stones, disturbances in the metabolism of zinc and copper, increased excitability of the central nervous system, sleep disturbance, and the development of microangiopathies.
Interaction - Increases blood concentrations of salicylates (increases the risk of crystalluria), ethinyl estradiol, benzylpenicillin and tetracyclines, reduces oral contraceptive use. Reduces the anticoagulant effect of coumarin derivatives. Improves the absorption of iron preparations in the intestines. Increases the total Cl of ethyl alcohol. Quinoline drugs, calcium chloride, salicylates, and corticosteroids deplete vitamin C reserves when used for a long time.
Overdose - No data available.
Special instructions - During long-term treatment, monitoring of renal function, blood pressure and glucose levels is necessary (especially when prescribing high doses). Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).
Literature - Encyclopedia of Medicines 2003