Azurophilic Grainity

Azurophilic granularity is a purple-colored granularity that is found in the cytoplasm of agranulocytic cells when stained with azur-eosin. This phenomenon is not permanent and can be caused by various reasons, such as inflammatory processes, infections, autoimmune diseases and others.

Azurophilic granules are intracellular structures containing various enzymes and proteins that are involved in the regulation of cellular metabolism. They can be found in a variety of cells in the body, including white blood cells, red blood cells, platelets, and smooth muscle cells.

When stained with an azur-eosin mixture, azurophilic grains acquire a bright purple color, which makes them easily visible against the background of the cytoplasm of agranulocytes. However, not all cells contain azurophilic granules, and its absence may indicate that the cell is dormant or not functioning properly.

One of the reasons why azurophilic granularity can be observed in cells is the inflammatory process. Inflammation is the body's defense response to various irritants such as bacteria, viruses, toxins and allergens. In response to inflammation, cells begin to produce various proteins and enzymes that help fight infection or other harmful factors.

In addition, azurophilic granularity can be observed in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and others. In these cases, the cells begin to attack themselves, producing antibodies that attack the body's own tissues.

Also, azurophilic granularity can be caused by various infections, for example, tuberculosis, syphilis and others. In these diseases, cells begin to secrete various waste products that can turn the cells purple.