Cardioxan

Cardioxan: an innovative medicine for the prevention of cardiotoxicity in cancer

Cardioxan is a lyophilized powder for the preparation of an infusion solution, created to prevent cardiotoxicity that can occur during the treatment of cancer with anthracyclines (doxorubicin, idarubicin, etc.). It is produced by the pharmaceutical company Kyron S.p.A. in the Netherlands, as well as Eurocetus Italy SPA in the Netherlands.

Cardioxan contains the active substance dexrazoxane, which is a complexing compound that prevents the cumulative chronic cardiotoxicity associated with anthracyclines. This is especially important for patients receiving long-term therapy with anthracyclines, as these drugs can cause serious side effects on the heart, including worsening heart function and the development of heart failure.

Cardioxan is recommended for the prevention of cardiotoxicity in oncological diseases, such as metastatic breast cancer, recurrent tumors after adjuvant therapy with anthracyclines, before or during radiation therapy, in patients with arterial hypertension, diabetes mellitus, in the elderly (over 65 years old) and children with cancer diseases, Kaposi's sarcoma against the background of AIDS (mono- or combination therapy).

Like most medications, Cardioxan has contraindications and side effects. Contraindications include hypersensitivity to dexrazoxane, pregnancy and breastfeeding. Side effects can be varied, including nausea, vomiting, diarrhea, hypocalcemia, weakness, dysfunction of the central nervous system, fever, infection up to sepsis, alopecia, leukopenia, thrombocytopenia, increased activity of liver transaminases, decreased hemoglobin, serum iron and vitamin B12. , increased levels of triglycerides and amylase, erythematous skin reactions; pain upon injection, phlebitis (when using undiluted drug); rarely - black coloring of nails.

Cardioxan is incompatible with other drugs and should be used with caution if liver or kidney function is impaired. Before starting to use Cardioxan, you should consult with your doctor and follow his recommendations on dosage and regimen.

Overall, Cardioxan is an innovative medicine that can significantly improve the quality of life of patients treated with anthracyclines by protecting their cardiac function from the negative effects of these drugs. However, like any medicine, it has its contraindications and side effects, so its use should only be done under the supervision of a physician.