Crohn's Disease

Crohn's Disease: Chronic inflammation of the gastrointestinal tract

Crohn's disease, also known as chronic transmural inflammation of the gastrointestinal tract, is a nonspecific disease of unknown etiology. It is characterized by the formation of inflammatory infiltrates, deep longitudinal ulcers and various complications such as perforations, fistulas, bleeding and other serious problems. Crohn's disease most often affects the distal ileum and colon and may also present as granulomatous colitis in the colon.

The symptoms and course of Crohn's disease can vary. Most often, patients suffer from diarrhea, abdominal pain, fever and loss of appetite. With local lesions, especially in the ileocecal region, general malaise and an increase in temperature to low-grade fever are possible. When palpating the abdomen, an infiltrate can be detected in the right half of the abdomen. Sometimes diagnosis of the disease becomes possible only after surgery, which reveals damage to the terminal ileum or ileocolitis. Extraintestinal manifestations of Crohn's disease include various complications such as sacroiliitis, ankylosing spondylitis, uveitis, primary sclerosing cholangitis, hydronephrosis and others.

Differential diagnosis of Crohn's disease includes x-ray examination, sigmoidoscopy, colonoscopy and biopsy. X-ray examination may reveal longitudinal ulcers and fissures, and biopsy may show deep plasma lymphocytic infiltration and sarcoid granulomas.

There is no specific therapy for Crohn's disease. Conservative treatment mainly consists of anticholinergic agents, loperamide, diphenoxylate, broad-spectrum antibiotics, metronidazole, sulfasalazine, and in severe cases, corticosteroids and immunosuppressants such as azathioprine and 6-mercaptopurine may be prescribed. In cases where conservative treatment is ineffective or severe complications such as perforation, bleeding or intestinal obstruction occur, surgery may be required to remove the affected areas of the intestinal tract.

Although Crohn's disease is chronic and incurable, symptoms can be controlled with treatment. It is also important to follow a special diet that can help reduce inflammation and relieve symptoms. In some cases, maintenance therapy may be required to maintain remission and prevent exacerbations.

However, it should be noted that my information is current as of September 2021, and new research and development may lead to new treatments and approaches to managing Crohn's disease. It is recommended that you consult a healthcare professional for the most up-to-date information about treatment for this condition.

Crohn's disease: understanding, symptoms and treatment

Crohn's disease, also known as Crohn's disease or granulomatous enteritis, is a chronic inflammatory disease of the digestive system. It is named after the American physician Barthaon W. Crohn, who first described this pathology in 1932. Crohn's disease belongs to a group of diseases known as inflammatory bowel diseases (IBD), which also include ulcerative colitis and unclassified colitis.

Crohn's disease can affect any part of the digestive tract, from the mouth to the anus. However, the lower parts of the small intestine and the area where the small and large intestines meet are most commonly affected. Characteristic signs of Crohn's disease include chronic inflammation of the intestinal wall, the formation of ulcers, granulomas (a certain type of inflammatory formation), and tissue scarring.

Symptoms of Crohn's disease can vary significantly depending on the location of the lesion and the degree of inflammation. Common symptoms are abdominal pain, diarrhea, bloody or mucus discharge from the rectum, loss of appetite, weight loss, fatigue and fever. Some patients may experience complications such as intestinal obstruction, abscesses, fistulas, and strictures (narrowings) in the intestines.

The cause of Crohn's disease is not completely clear. It is believed that genetic predisposition, a compromised immune system and the environment may play a role in the development of this disease. Some factors, such as smoking,

Crohn's disease, or regional ileitis, is a chronic inflammatory disease that affects the digestive tract. It is considered a rare pathology, but it is the most common cause of strictures in the lower gastrointestinal tract.

Identifies the primary disease