Curare-like Nondepolarizing Agents

Curare-like nondepolarizers (also known as curare-like antidepolarizers or pachycurares) are a class of medications used medically to relax skeletal muscles during surgery or other medical procedures.

These drugs get their name from their structural and functional similarity to the alkaloid curare, a natural poison that is used to hunt animals in parts of South America and was also used as an arrow poison by the Indians. Curare blocks the transmission of nerve impulses at neuromuscular junctions, which leads to skeletal muscle paralysis.

Curare-like non-depolarizing agents also block the transmission of nerve impulses at the neuromuscular junction, but they do so more selectively than curare and have a shorter duration of action. They bind to nicotinic-type receptors on the surface of muscle cells, thereby blocking the access of acetylcholine to the receptors and thereby preventing muscle contraction.

Curare-like non-depolarizing agents are used in anesthesiology to provide muscle relaxation during operations. They are used in combination with other anesthetic drugs such as barbiturates or inhalational anesthetics. Non-depolarizing curare-like agents may also be used to facilitate tracheal intubation or mechanical ventilation.

However, the use of these drugs may cause unwanted side effects such as hypotension, bradycardia, hyperkalemia and others. Also, it is necessary to take into account the possibility of developing allergic reactions to these drugs.

In conclusion, curare-like non-depolarizing drugs are an important class of drugs used in medicine to provide

Curare-like Non-depolarizing agents **Curare-like drugs** are chemical compounds that have a similar effect to curare. They are used medically to treat neurological diseases such as muscular dystonia, spasticity and myotonic syndrome. These drugs belong to the group of nerve agents