Decorin N20

Country of origin: Germany

Pharm-Group: Drugs with glucocorticosteroid activity

Manufacturers: Merck KGaA (Germany)

International name: Prednisolone

Synonyms: Decortin N5, Decortin N50, Inflanefran forte, Medopred, Novo-Prednisolone, Prednihexal, Prednisol, Prednisolone, Prednisolone, Prednisolone Nycomed, Prednisolone-Akos, Prednisolone-Rivofarm, Prednisolone acetate, Prednisolone ointment, Solyu-Decortin N10, Solyu-Decortin H20

Dosage forms: tablets 20 mg

Ingredients: Active substance - Prednisolone.

Indications for use: Systemic connective tissue diseases, systemic vasculitis, bronchial asthma, status asthmaticus, bronchitis, liver diseases, ulcerative colitis, enteritis, nephrotic syndrome, toxic neuropathy, polyneuritis, allergic diseases, adrenogenital syndrome, autoimmune hepatitis, glomerulonephritis, Addison's disease, immune hemolytic anemia, radiculitis, thrombocytopenia, hematoblastosis, hemetosarcoma, pemphigus, eczema, itching, exfoliative dermatitis, psoriasis, prurigo, seborrheic dermatitis, erythroderma, allergic conjunctivitis and blepharitis, inflammation of the cornea, scleritis and episcleritis, sympathetic ophthalmia, chronic arthritis, rheumatic myocarditis and pericarditis, epicondylitis, tendovaginitis, bursitis, humeroscapular periarthritis, keloids, sciatica, Dupuytren's contracture.

Contraindications: Peptic ulcer, decompensated diabetes mellitus, severe arterial hypertension, active form of tuberculosis, ospeoporosis, Itsenko-Cushing's disease, glaucoma, systemic mycoses, acute viral infection, productive symptoms in mental illness. Viral and bacterial eye diseases, primary glaucoma, corneal diseases with epithelial damage. Bacterial, fungal, viral skin lesions, tuberculosis, syphilis, skin tumors, pregnancy.

Side effects: Erosive and ulcerative lesions of the gastric mucosa, diabetes mellitus, osteoporosis, arterial hypertension, psychosis, Itsenko-Cushing syndrome, tachycardia, weakness, hypokalemia, fluid retention, adrenal insufficiency, decreased tissue repair processes, immunosuppression, decreased muscle mass, syndrome cancellation, exacerbation of the underlying disease (after withdrawal).

Interaction: Strengthens the anticoagulant effect of anticoagulants, increases the likelihood of gastrointestinal bleeding due to salicylates, disturbances of electrolyte metabolism due to diuretics, and the risk of intoxication with cardiac glycosides. Reduces the hypoglycemic effect of antidiabetic drugs, the antibacterial effect of rifampicin.

Overdose: Symptoms: headache, convulsions, heart failure, urticaria, rash, severe itching, fainting, soon after taking the drug. Treatment: stop taking. Urgent medical attention is required.

Special instructions: During the day, it is prescribed taking into account the circadian rhythm of endogenous secretion of corticosteroids (at 6-8 am). During the treatment process, observations by an ophthalmologist, monitoring of blood pressure, water and electrolyte balance, plasma sugar levels, and regular analyzes of the cellular composition of peripheral blood are necessary. To reduce side effects, the prescription of anabolic steroids is justified, as well as an increase in potassium intake. In Addison's disease, concomitant use of barbiturates should be avoided. For nonspecific infections and tuberculosis, use with caution. At the end of the course, it is recommended to consider the need for ACTH administration.

Literature:

1. Encyclopedia of drugs 2002
2. Griffith "Newest Medicines Vol. 2"