Dermatitis Chemical

**Chemical dermatitis** is an inflammatory skin disease caused by the action of various chemicals (provocateurs) on intact skin. The disease was first described in 1852 by K. Peter, who, together with G. Lederer, proved that its occurrence is due to the action of inorganic and organic acids. Subsequently, a theory appeared about the photochemical nature of T. Aspinus’ disease, which proves the role of ultraviolet radiation in pathogenesis. There are three main options for the development of chemical dermatitis: * toxicdermia (reaction to drugs) - the development of dermatitis several hours after the application of pharmacological drugs to the skin, for example: streptocide (suspension), chloramphenicol, veroshpiron;

* irritant dermatitis (maceration) develops when the skin comes into contact with substances that can cause irritation of the stratum corneum, for example, caustic alkalis, acids;

allergic contact dermatitis - occurs when certain chemicals act directly on the skin. Accompanied by the formation of primary edema (after 3-24 hours), the appearance of itching and erythema.

By the way, acute chemical allergies to medications occur in people with a hereditary tendency. The development of dermatitis is provoked by repeated use of the drug. In this case it is possible:

lichenoid reaction: pink or red swelling, blisters and papules with dry crusts develop at the site where the remedy appears. The diagnosis is confirmed by intradermal tests with the introduction of a substance into the dermis. Itching is felt after taking medications. Lofberg's spot is a stage of the lichenoid reaction after the cessation of the action of the provoking drug. The lesion is located on the inner surface of the forearm