Diaphyllin Gluteusum

Diaphylline gluteusum

Country of origin - Hungary
Pharm-Group - Bronchodilators - phosphodiesterase inhibitors

Manufacturers - Gedeon Richter A.O. (Hungary)
International name - Aminophylline
Synonyms - Aminomal, Aminophylline, Pharmafillin, Eufillin, Eufillin for injection
Dosage forms - solution for injection 24%
Composition - A mixture consisting of 80% theophylline and 20% ethylenediamine.

Indications for use: Chronic obstructive bronchitis, bronchial asthma, status asthmaticus (additional therapy), emphysema, neonatal apnea, Cheyne-Stokes respiration.

Contraindications - Hypersensitivity, acute gastritis, gastric and duodenal ulcers, arrhythmia, arterial hypertension, myocardial pathology, myocardial infarction, heart failure, prostate adenoma, diarrhea, fibrocystic mastopathy, alcoholism, cor pulmonale, fever, hypoxemia, infections respiratory tract, liver dysfunction, hyperthyroidism, chronic and acute renal failure, edema syndrome, hypernatremia, rectal diseases, lactation.

Side effects - Heartburn, vomiting, chest pain, palpitations, hypotension, headache, dizziness, flushing, tachypnea, allergic reactions (sweating, fever), reactions at the injection site.

Interaction - Increases the likelihood of developing side effects of glucocorticoids, mineralocorticoids, anesthetics, xanthines and central nervous system stimulants, beta-agonists. Reduces the specific activity of lithium salts. Oral contraceptives (estrogen-containing), antidiarrheal drugs, intestinal sorbents weaken, and H2-histamine blockers, fluoroquinolones, calcium channel blockers, beta-blockers, mexiletine, erythromycin enhance the effect of aminophylline.

Overdose - Symptoms: nausea, vomiting, pain in the epigastric region, gastrointestinal bleeding, anorexia, diarrhea, tachypnea, facial flushing, tachycardia, ventricular arrhythmias, insomnia, anxiety, photophobia, generalized convulsions. Treatment: drug withdrawal and maintenance therapy.

Special instructions - No data available.

Literature - Encyclopedia of Medicines 2004