Diapedesis

Diapedesis is the path that a blood particle passes through the vascular wall without damaging the internal barrier. This is a phenomenon in which red blood cells leak through the endothelial barrier into the vascular space. The diapedetic reaction is nonspecific. Activation leads to the dilation of blood vessels and an increase in their permeability. In this case, plasma particles enter the intercellular space and are exposed to complement. Destruction is carried out by the formation of edema (hyperemia) around the red blood cell, which is accompanied by its destruction. Thus, a blood clot forms.

Diapedesis is the passage of leukocytes through the vessel wall into nearby tissues, usually into inflammatory exudate. In the process of movement and interaction of leukocyte cells with tissue cells, functional transformation of leukocytes occurs (granulocytosis and monocytogenesis). Diapedesis of leukocytes begins from the moment when they accumulate in the microvasculature of the vessels surrounding the inflamed tissue. A small amount of plasma protein, fibrin, falls into the lumen of the vessels; it attaches to the collagen filaments, which are located in the walls of the vessels and glues the fibrin filaments together