Dose Tolerated Maximum

Maximum tolerated dose: what is it and why do you need to know?

The maximum tolerated dose (DL0) is a concept used in toxicology to indicate the highest dose of a substance that can be taken without causing any unwanted effects on the body. DL0 is an important tool in assessing the safety of drugs, food additives, pesticides and other chemicals.

Determination of DL0 is carried out by conducting toxicological studies on animals and assessing their response to various doses of the substance. This takes into account not only the presence of undesirable effects, but also their level of severity and temporary nature. The purpose of such studies is to determine a safe dose of a substance for humans.

For assessing drug safety, DL0 is an important reference point. Based on this indicator, dosage recommendations are developed, which may be different for different categories of patients, depending on their age, weight, gender and other factors.

DL0 is also used in assessing the safety of food additives and other chemicals that may enter the human body through food, water or air. In this case, DL0 is determined based on data on food consumption and other sources of the substance.

However, it must be understood that DL0 is not an absolute guarantee of security. In some cases, even small doses of a substance can cause unwanted effects in people with special sensitivities or under certain conditions. Therefore, it is important to follow the instructions for use of medications and other chemicals, as well as monitor the quality and safety of food products.

In conclusion, DL0 is an important tool for assessing the safety of chemicals used in medicine, food processing and other industries. However, when using it, it is necessary to take into account the individual characteristics of a person and follow the recommendations for the use of the substance.

A dose that affects vital organs and leads to the death of animals (most often horses during the foaling period), causing irreversible changes in the body that are incompatible with life.

The term “maximum tolerated” was introduced into veterinary medicine by T. N. Edemsky and is synonymous with the term “D93”. This term is usually understood as a certain dose of an antigen, upon administration of which a healthy animal, sensitized to this antigen, develops characteristic clinical signs after contact with this allergen. The maximum tolerated dose is considered the threshold, i.e. the smallest dose that leads to characteristic manifestations of the host reaction, although its development is preceded by contact of the recipient animal with the allergen-antigen.

Determining the type of reaction of an animal's body (whether an emergency complex of a local or systemic type develops) using clinical methods for a long time led to errors, both due to the ambiguity of the very definition of the word reactivity, and due to incorrect sampling for the reaction. Understanding this required more accurate methods for analyzing biomaterial and led to the use of immunological tests, among which the most effective and popular were methods for determining the level of serological indicators of blood serum, which allow making not only a qualitative, but also a quantitative assessment of the strength of immunity during testing. The development of serological research methods in veterinary medicine has been a significant breakthrough in the practice of veterinary diagnostics, making it possible to identify hidden forms of the immune response that cause the formation of foci of invasion and disease, as well as classify them by stage of development before the appearance of clinical signs. Not only the diagnosis of infectious diseases, but also those types of health pathologies that do not have a specific clinical picture during the life of the animal have become more accessible. These include tumors, developmental anomalies, chromosomal syndromes, and immune pathological processes. In addition, it became possible to determine the etiology of diseases and establish its main symptoms with a high degree of accuracy and reliability.