Fibrinogen (Fibrinogen)

Fibrinogen - a blood clotting factor - is a soluble protein, a precursor of fibrin, present in blood plasma. Under the influence of the enzyme thrombin, the insoluble protein fibrin is formed from fibrinogen at the final stage of blood clotting. The normal content of fibrinogen in blood plasma is 2-4 g/l (in pregnant women it is 4-6 g/l).

Fibrinogens are one of the most important proteins in the human blood coagulation system. They play a key role in the formation of fibrin, an insoluble protein that binds to various elements of the blood, forming a blood clot and stopping bleeding. Fibrin formation occurs under the influence of the enzyme thrombin.

Fibrinogenesis is a complex process that leads to the formation of fibrin threads - a specific blood plasma protein that are formed during the process of coagulation (clotting). Fibrin is an integral part of hemostasis and is responsible for stopping bleeding.

Fibrinogen is a soluble protein fraction of plasma that is broken down by thrombin to form insoluble fibrin. Fibrinogen protein is synthesized in the liver and the cells that synthesize it. In essence, it is a “risk enzyme” for patients with disorders of the blood coagulation system. Increased fibrin content

Fibrinogeni

Fibrinogens are clotting factors, plasma-soluble proteins. Through the action of platelets, fibrinogens are converted into insoluble fibrins. In the human body, the fibrinogen complex performs two important functions: it ensures the formation of blood clots and prevents blood loss.

Fibrinogens are produced in the liver, but they are constantly present in the plasma. There are very few of them on the surface of cell membranes. Therefore, fibrinogen balance depends on the rate of production and the degree of utilization of these proteins.

Fibrinogens are independently synthesized by the liver and are also secreted by B-lymphocytes in the bone marrow. Precursors also enter the body with food: fatty meat, beer, mushrooms, buckwheat. These foods are sources of the amino acid proline. It is under the influence of proline that fibrinogenic peptides are obtained. The conversion of protein into fiber occurs most actively in women, which means that this protein can also perform a reproductive function. Normal fibrinogen levels range from 2 to 5 g/liter. The age range of a healthy indicator ranges from 5 to 20%. According to the instructions, determination of the level of this coagulation fraction can be carried out either manually or by electromechanical and immunochemical methods.