Fibroblast

Fibroblast is the main specialized cell widespread in connective tissue, which synthesizes and secretes the main components of the intercellular substance - polysaccharides, collagen precursors, from which collagen, elastic and reticular fibers are formed.

Fibroblasts play a key role in the synthesis of the main substance of connective tissue. They are responsible for the production of collagen, glycosaminoglycans, proteoglycans and other proteins of the intercellular matrix. In addition, fibroblasts regulate the processes of differentiation, migration and proliferation of other cells. They are involved in reparative processes and wound healing, as well as in inflammatory reactions and tissue fibrosis. Dysfunction of fibroblasts underlies many pathological conditions of connective tissue.

Fibroblastic cells: basic information Fibroblasts are a type of connective tissue. It is represented by cells that synthesize intermediate metabolites in the process of synthesis of the intercellular matrix and have a certain structural and functional unit with various specific properties, but a single organization. In general, fibrosis is a process of excessive tissue neovascularization.

The proliferation of collagen fibers leads to their aging, as a result of which the tissues lose their mechanical strength and elasticity. Thanks to non-invasive diagnostic methods, it is possible to assess the degree of fibrosis, as well as its localization, extent and, with localization accuracy, describe the detected areas of fibronectin and ECM protein according to the degree and nature of abnormal hyperplasia.

Fibrovasculitis is an inflammatory process that promotes sclerosis of the stroma of the vascular wall or inflammation of the interlobular stroma due to the rejection of free neutrophils into it. Replacement with healthy connective tissue occurs. Fibrosis (fibrosclerosis) of the heart is regarded as an irreversible process that compensates for damage to cardiomyocytes in dilated, hypertrophic cardiomyopathies, and ischemic heart disease. For post-tuberculosis fibrosis

Fibroblasts are multinucleated connective tissue cells with a well-developed nucleus. Identical cells, interconnected by processes of the cytoplasm, are located next to each other and form so-called fibroblastic clusters. They are the main component of connective tissue.

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