Phosphorylthiocholines

Phosphorylthiocholines: Potent organophosphate poisons

Phosphorylthiocholines are a group of organophosphorus toxic substances that are particularly toxic, especially when exposed through the skin. These chemical compounds are widely known for their deadly effectiveness and have been used in the past as chemical weapons. In this article, we will look at the main characteristics of phosphorylthiocholines, their mechanisms of action in the body, and the importance of taking appropriate precautions to ensure safety.

Phosphorylthiocholines belong to a class of organic compounds containing phosphorus and sulfur atoms. They are highly toxic and can cause serious poisoning in humans. The most famous representatives of phosphorylthiocholines are sarin, soman and vxin.

The mechanism of action of phosphorylthiocholines is their ability to inhibit the activity of enzymes called cholinesterases. Cholinesterases play an important role in the nervous system by controlling the transmission of nerve impulses. When exposed to phosphorylthiocholines, they are blocked, which leads to the accumulation of the neurotransmitter acetylcholine and disruption of the normal function of the nervous system. It causes severe neurological symptoms including muscle weakness, seizures, paralysis and can ultimately lead to respiratory failure and death.

Exposure to phosphorylthiocholines through the skin is especially dangerous. These substances can quickly penetrate the skin and enter the bloodstream, causing systemic poisoning. Exposure to phosphorylthiocholines can occur through a variety of sources, including industrial accidents, use of chemical weapons, or mishandling of chemicals.

To ensure safety, a number of precautions must be observed when working with phosphorylthiocholines. First, appropriate personal protective equipment such as protective suits, respirators and gloves must be used to prevent contact with skin, respiratory tract and mucous membranes. Secondly, it is necessary to follow strict rules for handling chemicals and store them in safe conditions, according to the recommendations and instructions of the manufacturer.

In conclusion, phosphorylthiocholines are a group of organophosphorus toxicants with high toxicity, especially when exposed through the skin. Their mechanism of action is to inhibit cholinesterases and disrupt the normal function of the nervous system. In this regard, it is necessary to take all possible precautions when working with phosphorylthiocholines to ensure safety and prevent possible poisoning.

Phosphori-liothiocholines This is a group of organophosphorus toxic substances, characterized by particularly high toxicity, especially when exposed through the skin. Phosphoryl thiocholine was created for the development of a new means of combating combat beetles and beetles in the 40-50s of the 20th century.

In the group of phosphorylthiochlorins, the first place is occupied by well-studied insecticides: diphenylthiocarbamate, diazophos, thiocyanate, carbonyl tetrachloride. Small inorganic organophosphorus compounds include a number of compounds (tricyclodic triflate, picroline, etc.) previously used as moth control agents. At the beginning of the 20th century, niklofos was synthesized; it persistently bound to the phospholipids of insect nerves, gradually hydrolyzing under the influence of trynapsin. 15 years have passed since the synthesis of clonaphor was carried out in the USA from clolidor (the closest analogue of niklofos), the development of which was completed. Cymox is an organophosphate insecticide.