Country of origin - Canada
Pharm-Group - Combined antimicrobial agents
Manufacturers - Genfarm Inc (Canada)
International name - Co-trimoxazole
Synonyms - Apo-Sulfatrim, Baktekod, Baktoreduct, Bactrim, Bactrim forte, Berlocid, Berlocid 240, Berlocid 480, Berlocid 960, Bi-Septin, Bikotrim, Biseptol, Biseptol 480, Bisutrim, Brifeseptol, Groseptol, Dvaseptol, Disepton, Duo-Septol , Intrim, Co-trimoxazole, Co-t
Dosage forms - tablets 480 mg, tablets 960 mg
Composition - Composition: Sulfamethoxazole + Trimethoprim.
Indications for use - Respiratory tract infections: bronchitis (acute and chronic, prevention of relapses), bronchiectasis, pleural empyema, lung abscess, pneumonia (treatment and prevention), incl. caused by Pneumocystis carinii in patients with AIDS; urinary tract: urethritis, cystitis, pyelitis, pyelonephritis, prostatitis, epididymitis; urogenital: gonorrhea, chancroid, lymphogranuloma venereum, granuloma inguinale; Gastrointestinal tract: bacterial diarrhea, shigellosis, cholera (as part of combination therapy), typhoid fever and paratyphoid fever (including bacterial carriage), cholecystitis, cholangitis, gastroenteritis caused by enterotoxic strains of E. coli; skin and soft tissues: acne, furunculosis, pyoderma, erysipelas, wound infections, soft tissue abscesses; ENT organs: otitis media, sinusitis, laryngitis; surgical; septicemia, meningitis, osteomyelitis (acute and chronic), brain abscess, acute brucellosis, South American blastomycosis, malaria (Plasmodium falciparum), toxoplasmosis and whooping cough (as part of complex therapy).
Contraindications - Hypersensitivity (including to sulfonamides or trimethoprim), liver or kidney failure, B12-deficiency anemia, agranulocytosis, leukopenia, glucose-6-phosphate dehydrogenase deficiency, pregnancy, breastfeeding, children's age (up to 2 months - for oral , up to 6 years - for parenteral administration), hyperbilirubinemia in children.
Side effects - From the gastrointestinal tract: dyspepsia, nausea, vomiting, anorexia, rarely - cholestatic and necrotic hepatitis, increased transaminases and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis. From the hematopoietic organs: agranulocytosis, aplastic anemia, thrombocytopenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia. From the urinary system: crystalluria, renal failure, interstitial nephritis, increased plasma creatinine, toxic nephropathy with oliguria and anuria. Allergic reactions: urticaria, rash, toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, allergic myocarditis, erythema multiforme, exfoliative dermatitis, Quincke's edema, itching, redness of the sclera, increased body temperature. Others: hyperkalemia, hyponatremia, aseptic meningitis, peripheral neuritis, headache, depression, arthralgia, myalgia, weakness, photosensitivity .
Interaction - NSAIDs, antidiabetic drugs (sulfonylurea derivatives), diphenin, indirect anticoagulants, thiazide diuretics, barbiturates enhance therapeutic (and side) effects (displace them from the connection with plasma proteins and increase the concentration in the blood), anesthesin and novocaine - reduce (because As a result of their hydrolysis, PABA is formed). Hexamethylenetetramine (urotropine), ascorbic acid increase crystalluria (cause acidification of urine). Increases the effect of phenytoin, diphenin, warfarin. Reduces the reliability of oral contraception (inhibits intestinal microfl