Gen-Zolerol

Country of origin - Canada
Pharm-Group - Products for the treatment of trichomoniasis, amebiasis and other protozoal infections

Manufacturers - Genfarm Inc (Canada)
International name - Metronidazole
Synonyms - Aquametro, Apo-Metronidazole, Arilin, Deflamon, Zoacid, Camezol, Klion, Medazol, Metrovit, Metrogyl, Metroxan, Metrolacare, Metronidazole, Metronidazole IV Brown, Metronidazole Kvalimed, Metronidazole Nycomed, Metronidazole-AKOS, Metronidazole-Ros, Metronidazole
Dosage forms - tablets 200 mg, tablets 400 mg
Composition - Active substance - metronidazole.
Indications for use - Amebiasis, trichomoniasis, giardiasis, giardiasis, intra-abdominal infections (peritonitis, abscess), anaerobic infections of bones and joints, skin and soft tissues, female genital organs (endometritis, tubo-ovarian abscess), central nervous system (meningitis, brain abscess), lower respiratory tract (pneumonia, empyema, lung abscess), endocarditis, pseudomembranous colitis, eradication of Helicobacter pylori, chronic alcoholism, prevention of postoperative anaerobic infection. For external and local use: rosacea and vulgar acne, bacterial vaginosis, long-term non-healing wounds, trophic ulcers.
Contraindications - Hypersensitivity (including to other nitroimidazole derivatives), pregnancy, lactation, children (excluding cases of amoebiasis).
Side effects - Headache, dizziness, syncope, ataxia, disturbances of consciousness, epileptic seizures, neutropenia (leukopenia), nausea, vomiting, abdominal pain, diarrhea, unpleasant metallic taste, erythematous rashes, skin itching, dark coloration of urine, allergic reactions, thrombophlebitis (after intravenous administration).
Interaction - Enhances the effects of indirect anticoagulants and lithium salts. Phenytoin and phenobarbital reduce the effect (due to activation of the liver microsomal system and accelerate metabolism and excretion), and cimetidine increases (inhibits the enzymatic systems of the liver and, as a result, slows down biotransformation). Incompatible with alcohol (when taken together, an Antabuse-like syndrome develops).
Overdose - Symptoms: nausea, vomiting, ataxia, in severe cases - peripheral neuropathy and epileptic seizures. Treatment: symptomatic; There are no specific antidotes.
Special instructions - When treating with metronidazole, excessive development of fungal flora of the vagina (candidiasis) is sometimes observed, which requires the prescription of antifungal drugs.
Literature - Encyclopedia of Medicines 2006 Directory of medicines M.D. Mashkovsky 14th edition 2000, Encyclopedia of Medicines 9th edition 2002. Medicines M.D. Mashkovsky 14th edition. Antimicrobial and antiviral drugs issue 3.