Hepatitis Experimental

Hepatitis experimental

Experimental hepatitis is a group of liver diseases that are caused by the action of damaging factors on the liver in animals. These factors can be different, for example, carbon tetrachloride, alcohol, phenylhydrazine and others.

Experimental hepatitis is an important model for studying the mechanisms of liver injury and repair. It allows us to study the mechanisms of inflammation, fibrosis and liver regeneration, as well as investigate the effectiveness of new treatments.

Experimental hepatitis research is carried out in various laboratories around the world. They allow us to improve our understanding of the mechanisms of liver damage and develop new methods for treating liver diseases.

Currently, experimental hepatitis is one of the most pressing problems in medicine, since many people suffer from various forms of hepatitis, including viral hepatitis. Therefore, research on experimental hepatitis is of great importance for the development of new methods of treatment and prevention of liver diseases.

Hepatitis A and the pathogenesis of the disease Hepatitis A is an acute viral infection caused by the hepatitis A virus (HCV), characterized by a cyclical course of the disease. The virus is transmitted through contaminated food and water. The peak incidence occurs in the spring. Children aged 3 to 9 years are most often affected (approximately 80% of cases).

After the virus enters the body, it multiplies in the liver, spreading first along the bile ducts and then throughout the liver. It is known that after penetration into the blood, hepatitis A viruses, finding cells susceptible to them, remain motionless, without causing pathological changes. The virus exhibits pathogenic properties only in the absence of this barrier. Only this can explain the undulating course of the disease.

The liver is usually able to trap the infection within itself, completely clearing it without intervention; all changes are transitory in nature. Therefore, self-healing is possible. Very rarely, after an acute process, residual persistent virus carriage occurs, which is clinically undetectable, since the concentration of the virus in the blood is very low, and its reproduction has completely stopped. The disease can occur subclinically, without jaundice; this disease does not affect liver cells. Such