Itrazol

Itrazole: an antifungal agent for the effective treatment of fungal infections

Itrazole is an antifungal agent belonging to the group of imidazole and triazole derivatives. Its international name is Itraconazole. The drug is produced by the Russian pharmaceutical company Vertex and is available in the form of 100 mg capsules.

Itrazole has a wide range of uses and is effective in treating various fungal infections. It is used to treat onychomycosis (fungal infection of the nails), mycoses of the skin, oral cavity and eyes caused by dermatophytes, yeasts and molds, as well as systemic tropical mycoses and vulvovaginal candidiasis.

Before using the drug, some contraindications must be taken into account. Itrazole is not recommended in case of hypersensitivity to the drug, as well as during pregnancy and lactation.

Side effects may occur when using itrazole. Possible dyspepsia, abdominal pain, constipation, hepatitis, increased appetite, headache, dizziness, peripheral neuropathies, dysmenorrhea, increased levels of transaminases in the blood plasma, itching, thrombocytopenia, leukopenia, prolongation of bleeding time, edema, hypokalemia, weight gain, hyperammonemia , alopecia, angioedema, urticaria and itching. If you experience any unusual or unpleasant symptoms while taking this drug, you should consult your doctor.

Itrazole may interact with other medicines. It is incompatible with terfenadine, astemizole, lovastatin, oral forms of midazolam and triazolam. The drug also enhances and/or prolongs the effect of oral anticoagulants, cyclosporine A, digoxin, methylprednisolone, warfarin, vincristine and calcium channel blockers. Rifampicin and phenytoin reduce the bioavailability of itrazole; antacid drugs can slow down absorption (at least 2 hours must pass between doses of drugs).

There is no information about overdose with itrazole, however, if you suspect an overdose, you should immediately consult a doctor or the nearest hospital.

Particular caution should be exercised when using itrazole in patients with liver cirrhosis and/or renal impairment. In such cases, a dose adjustment of the drug may be required.

Long-term use of itrazole may cause accumulation of the drug in the body, especially in patients with impaired liver and kidney function. Therefore, it is recommended to periodically monitor the level of itrazole in the blood and, if necessary, adjust the dosage.

In general, itrazole is an effective antifungal agent, but its use should be under medical supervision. Before starting treatment, you must consult a specialist and follow his recommendations on the dosage and duration of taking the drug.