Isoantigen Diego System

Diego system isoantigen (syn. Diego system antigens) is a group of antigens that were discovered at the beginning of the 20th century by the German immunologist Otto Diego and his colleagues. These antigens are components of white blood cells, red blood cells and other blood cells and play an important role in the human immune system.

Diego system antigens were discovered in 1915 when Otto Diego conducted research on mice infected with bacteria. He discovered that certain bacteria can cause antibodies to form in the blood of mice that will attack these bacteria. Diego theorized that these antibodies were associated with certain antigens on the surface of the bacteria.

Subsequent studies showed that antigens of the Diego system are present not only in bacteria, but also in human blood cells. These antigens have been found to play an important role in protecting the body from infections and other diseases.

One of the main properties of Diego system antigens is their ability to stimulate the human immune system. When the body encounters an antigen, the immune system begins to produce antibodies that can attack and destroy foreign cells.

In addition, antigens of the Diego system can be used in medicine to diagnose various diseases and determine the immune status of a person. For example, a blood test for Diego system antigens can help determine whether a person is allergic to certain foods or medications.

Thus, Diego system antigens are an important component of the human immune system and play an important role in protection against infections and diseases.

The isoantigen of the Diego system (Diego is a term introduced into the literature by M.A. Zaitsev in 1976) is a group of human and animal antigens that cause the formation of autoantibodies (Dosser system antigens) directed against the nucleus of lymphocytes (sectors). Systemic autoimmune diseases are predominantly caused by the formation of excess production of autoantibodies - T and B cells, which are components of the immune system. Although the forms of this pathology are not directly associated with parasitic infections, in some cases the connection between systemic autoimmune diseases and parasitosis or invasion is confirmed.

Isoantigens of the Diego system are responsible for a specific membrane marker of certain tissue groups. They are glycoproteins whose molecules are associated with lipids and glucose. When glycoprotein molecules bind to antibodies, they can bind to other glycoprotein molecules and form complexes that promote cell destruction.

Diego systems are isotypic markers for the normal and pathological hematological spectrum of various tissues and cell fragments. They are divided into the ISD1 superfamily and the ISD2 superfamily. Each superfamily is divided into alpha and beta and some other subtypes of molecules. Many of these systems are immunologically identical and have unique cell surface markers due to their unique amino acid sequences. In many cases, these isotropic markers are specific to many different human blood tissue samples and represent different fragments of a person's chromosomes.

The biochemical properties of Diego isoantigens, their belonging to the superfamily of ISD1 systems, the homology of certain complexes of glycoprotein molecules, are usually used to determine the biological nature of the tumor.