Ketorolac

Ketorolac: use, side effects and interactions with other drugs

Ketorolac, also known as Toradol, is an anti-inflammatory drug used to relieve moderate to severe pain. In this article we will look at the main characteristics, application, side effects and interactions of ketorolac with other drugs.

Ketorolac is produced in Ukraine by Lekhim-Kharkov, as well as in Russia by Sintez AKO, Kurgan and Sotex PharmFirma. It belongs to the group of anti-inflammatory drugs - derivatives of pyrrolizinecarboxylic acid.

Ketorolac is available in the form of tablets of 10 mg and a solution for intramuscular injection with a concentration of 30 mg/ml. Its active substance is ketorolac.

The drug is used to relieve joint pain due to injuries with ligament rupture, dislocations, sprains, as well as to treat back and muscle pain. In addition, it can be used to relieve post-operative pain.

However, the use of ketorolac has a number of contraindications. It is not recommended for hypersensitivity to aspirin and other NSAIDs, nasal polyps, angioedema, bronchospasm, bronchial asthma, gastric and duodenal ulcers, impaired renal function, hypovolemia, dehydration, high risk of postoperative bleeding or incomplete stopping of bleeding, impaired hematopoiesis, hemorrhage in the brain, pregnancy, breastfeeding (breastfeeding must be stopped during treatment) and early childhood (up to 2 years).

Side effects of ketorolac may include dry mouth, dyspepsia, gastrointestinal pain, nausea, vomiting, diarrhea, feeling of fullness, peptic ulcers, gastritis, liver dysfunction, flatulence, black stool, constipation, rectal bleeding, stomatitis, headache, pallor, dizziness, nervousness, depression, drowsiness, asthenia, sweating, edema, dyspnea, bronchial asthma, impaired taste and vision, vasodilation, increased urination, oliguria, glomerulonephritis, nephrotic syndrome, renal failure, hyperkalemia, hypertension, heart failure, heart rhythm disturbances, anemia, thrombocytopenia, allergic reactions, including anaphylactic shock.

Ketorolac may interact with certain other drugs, including anticoagulants, antiplatelet agents, corticosteroids, alcohol, digoxin, lithium, methotrexate, antiarrhythmic drugs, ACE inhibitors, diuretics, antimicrobial agents and other NSAIDs.

When using ketorolac, you should be careful and consult your doctor, especially if you have any medical conditions or are taking other medications. It is also necessary to follow the recommendations for dosage and duration of treatment to avoid possible side effects.