Concentration Lethal Medium

The lethal mean concentration is the level of exposure to a chemical that kills half of the animals tested within a specified period of time. The median lethal concentration (CL50) is the dosage of a given substance that causes death in 50% of experimental animals. The value of this indicator is used in chemical research as an effective way to assess the toxicity of inorganic, organic and polymeric substances. CL50 values ​​allow you to compare the toxicity of different compounds with each other and select the safest and most effective compounds for use. This is a very important value if there are many hazardous chemicals, then the dose at which harmful chemicals remain in animals must be limited to a low value so that those who may work with these substances are protected. This can also help in choosing protection for work areas. Although this is a fairly important indicator, it can be improved. The use of different dose sizes or types of subjects helps to more accurately determine the level of lethal effects of a compound on the body. More accurate exposure assessment methods, such as electronic detection analyzers, can also improve these indicators. CL50 levels may vary depending on the animal species and testing conditions. In humans, CL50 values ​​are much higher