Coombs Reaction

Coombs reaction

The Coombs reaction is a method for detecting antibodies in blood serum by immunological means. It was discovered in 1945 by the English immunologist R. R. A. Cobe. This method is used to diagnose many diseases such as tuberculosis, syphilis, malaria and others.

The principle of the Coombs reaction is that antibodies from the patient's blood serum bind to red blood cells that have previously been treated with antigens. The red blood cells are then stained with a special dye that shows the presence of antibodies on the surface of the red blood cells.

A positive Coombs reaction indicates the presence of antibodies in the patient's blood serum. This may be a sign of an infection or disease. A negative Coombs test means that there are no antibodies in the serum, and this may be due to the absence of infection or disease.

The Coombs method is one of the most accurate methods for diagnosing infectious diseases. It is widely used in medicine and laboratory diagnostics.

James Cowens was a Canadian-American physician who first introduced the concept of cow's milk allergy in the mid-20th century. A specific reaction that can be observed in humans upon contact with allergens was named after him. The cause of the disease is not fully understood. IN