L-Thyroxine

L-Thyroxine: description, application and side effects

L-thyroxine is a drug that stimulates the function of the thyroid gland. It is produced in Germany by Henning Berlin GmbH and is used for the treatment of hypothyroid conditions of various etiologies, as well as for suppressive thyroid therapy of simple goiter, autoimmune Hashimoto's thyroiditis, multinodular goiter and thyrostatic treatment of hyperthyroidism. The drug is also used for the prevention of goiter recurrence after resection, conducting a suppression scintigraphic test of the thyroid gland and in the complex therapy of thyrotropin-dependent well-differentiated papillary or follicular carcinomas of the thyroid gland.

L-thyroxine is produced in the form of tablets that contain the active ingredient - sodium levothyroxine. The dosage of the drug is 100 mcg. Contraindications to use include hypersensitivity to the drug, untreated thyrotoxicosis, acute myocardial infarction, severe hypertension, angina pectoris, myocarditis, heart failure, tachysystolic arrhythmias, old age (over 65 years) and uncorrected dysfunction of the adrenal cortex.

When using L-thyroxine, side effects may occur, such as tachycardia, rhythm disturbances, chest pain, tremor, insomnia, anxiety, hyperhidrosis, alopecia, weight loss, diarrhea, dysfunction of the adrenal glands in pituitary or hypothalamic hypothyroidism, renal function disorders in children.

The interaction of L-thyroxine with other drugs can lead to a change in its effectiveness. The drug reduces the effect of insulin and oral antidiabetic drugs, cardiac glycosides, and enhances the effect of indirect anticoagulants and tricyclic antidepressants. Phenobarbital and phenytoin accelerate metabolic Cl without increasing the proportion of free T3 and T4 in the blood. Cholestyramine, colestipol, aluminum hydroxide reduce plasma concentrations by inhibiting absorption in the intestine. Protein binding is altered by anabolic steroids, asparaginase, clofibrate, furosemide, salicylates, tamoxifen. Estrogens increase protein binding, which can lead to an increase in the dosage of L-thyroxine.

Before starting to use L-thyroxine, you should consult your doctor and undergo regular examinations to monitor the level of thyroid hormones. If side effects occur, seek medical attention.

It is important to remember that self-medication with L-thyroxine can be hazardous to health and lead to serious complications.