Fever Monocytic Eosinophilic

Monocyte-eosinophilic fever (MEF) is an acute infectious disease caused by human herpes viruses types 6B and 7. This type of fever is characterized by high body temperature, fever, general weakness and fatigue, as well as eosinophilia and mild monocytosis.

The history of this disease dates back to 1995, when a fever with the following symptoms was described in Saudi Arabia: • body temperature above 38°C; • bleeding gums; • hemorrhages on the skin; • stomach ache; • diarrhea; • joint pain. Over the course of several years, a significant number of cases of this disease were described, but only in 2016 was the causative agent of the fever identified - a virus that belongs to human herpes type 7B.

Symptoms of the disease may include high fever, headache, general malaise, diarrhea, nausea, vomiting and abdominal pain. In addition, there is swelling of the mucous membrane of the throat and nose, lymphadenopathy, enlargement of the liver and spleen, as well as an increase in the number of red and white blood cells in the blood. The fever can last from several days to several weeks, and after recovery, most people develop immunity to the virus. However, some patients may experience reinfection, especially if their immune system is weakened.

Treatment for FEBME includes the use of antimicrobial drugs, such as acyclovir or valacyclovir, which help suppress the virus and reduce fever symptoms. Replacement therapy may also be used to reduce fluid and electrolyte deficiencies caused by high fever and vomiting.

It is important to note that diagnosing FEBME can be difficult as the symptoms of this disease can be similar to other infectious diseases. Therefore, if you suspect you have this disease, you need to consult a doctor for tests and an accurate diagnosis.

Overall, FEBME is a dangerous disease that can lead to serious complications if not treated correctly. Therefore, it is extremely important to seek medical help promptly and follow your doctor’s recommendations to improve the prognosis and speed up recovery.

Monocyte eosinophic fever is a condition of the body in which there is an increased number of white blood cells, in particular monocytes and eosinophils, as well as increased body temperature. This is a serious disease that can have various causes and complications.

Monocytes are cells of the immune system that are capable of phagocytosis, that is, the absorption and destruction of foreign particles. Eosionophils are a type of white blood cell that is released during allergic reactions. A high level of monocytes in the blood indicates that the body is fighting an infectious disease or inflammatory process. However, sometimes high monocyte counts can be a sign of other diseases, such as cancer or HIV infection.

Eosinophils play an important role in allergic reactions and resistance to parasites. They can also cause tissue inflammation and cell damage, leading to swelling and pain.

Infectious agents or autoimmune processes can cause a large number of eosinphils in the body; they are responsible for cleansing and healing tissues

Monocyte eosimonphilic fever

Monocetomic eosinphilic fever is a syndrome accompanied by an increase in body temperature, an increase in the number of monocytes and eosinophils in the peripheral blood, swelling of the face, migraines and other symptoms, sometimes the presence of a skin rash.

**Etiology, pathogenesis.** In the etiology of the disease, great importance is attached to the human leukemia virus. Allergies, parasites, metabolic characteristics and immunodeficiency states, and infectious diseases have a certain influence on the occurrence of the disease. The pathogenesis of the disease is based on the formation of an immune response to the virus, the formation of cytotoxic T cells, and the activation of cationic proteins in phagocytes (monocytes). **Clinical picture.** The disease is accompanied by the following clinical manifestations: febrile temperature, which reaches 38-39 °C, a broken state, pain in the head and muscle pain. The presence of the disease is indicated by a characteristic change, the red-purple color of the skin. A skin rash may also occur, accompanied by muscle and joint pain. In addition, damage to small arteries may occur. There is a significant expansion of the capillaries, reminiscent of their damage or sticking together. Changes in internal organs are also observed, such as enlargement of the liver and spleen, hemorrhages under the pleura. This is evidenced by characteristic changes according to the results of x-ray examination. There is a significant increase in the level of eosinophils in the blood. Symptoms of intoxication appear. **Treatment.** Treatment of eosinphil monocytic fever depends on the cause that caused it. For viral infections, antiviral drugs are prescribed. If an allergic reaction occurs, antihistamines are used. To reduce the severity of intoxication symptoms, water-salt solutions are used. It is recommended to take medications that improve blood circulation and metabolism in the body.