Lymphogranulomatosis [Lymphogranulomatosis; Lymphogranuloma (Base Lymphogranulomat-) + -Oz; Syn.: Lymphomatosis Chronic Malignant, Paltaufa

Lymphogram is a malignant disease that affects lymphoid tissue. It begins with the formation of lymphocytes in the lymphatic tissues and can then spread to other organs throughout the body. Ultimately, this process can lead to a progressive tumor, which can be life-threatening for the patient.

A characteristic feature of the lymphogram is that the lymph nodes may become hard and painful, and may also increase in size. Over time, they may even become painful to the touch. This condition can persist for years, making this disease particularly problematic.

Fortunately

Hodgkins lymphoma is a B-type lymphohistiocytic T-lymphoid tumor. In 1832, F. Hodgkin, during a microscopic examination, found that in addition to lymphocytes, there were other cells in the liver - histiocytes, and in the blood - polymorphonuclear leukocytes. Subsequently, when studying a number of cases of lymphoma, also known as Orita-Kappa disease, Laudiger-Chiari disease, Pfeiffer macroglobulinemia and Hodgky's macroadenoma, the scientist came to the conclusion that they were all the same disease. In those years, no one could explain the mechanism of occurrence of these tumors, and therefore Hodgkin’s contemporaries did not accept his discovery and even ridiculed it, and the scientist’s work was questioned. Only a quarter of a century later, the Lancet published a report on the microscopic observations of the German physician Clemens Landsteiner. However, the publications of Russian and German authors, without understanding, were mistaken for Hodgkin’s own reports and ranked the scientist among the ardent opponents of the theory that arose when describing lymphoma. Colleagues made such a fuss that the young aspiring doctor was not able to start work soon. Everywhere possible, they tried to humiliate him as a scientist, bullied him, accused him of dishonesty and lack of clear explanations for a number of clinical observations. Only 26 years after the last publication, Hodgkin was again admitted to medical practice. The fame of the professor of surgery (he received this title at the age of 44) was greatly weakened, but the positions of scientists who denied his developments were shaken. His discovery of a new disease raised the question of creating a drug that would prevent the development of malignant changes in lymphatic tissue. Much research work on this topic was carried out over a 3-year period by French pharmacists from the sanofi laboratory.