Metmyoglobin

Metmyoglobin is a derivative of the myoglobin molecule (a protein that carries oxygen in the blood), which is formed in the body as a result of poisoning with certain substances. Myoglobin is one of the most important proteins in the body, and its function is to carry oxygen to tissues. When myoglobin is exposed to toxins such as heavy metals or certain drugs, the heme iron in its structure can become ferric, making it unable to carry oxygen. This leads to the formation of metmyoglobin in the body.

Metmyoglobin can be found in blood, urine, saliva and other body fluids, and can be used to diagnose some diseases associated with poisoning. For example, metmyoglobin is often used to monitor the body's exposure to heavy metals such as mercury, lead, or arsenic. In addition, metmyoglobin can also be used to determine blood oxygen levels and monitor the condition of patients with lung diseases such as chronic obstructive pulmonary disease (COPD).

However, it is worth noting that metmyoglobin is not the only indicator of heavy metal poisoning. Other biomarkers such as sulfhydryl groups and metallothionein can also be used to diagnose poisoning.

Overall, metmyoglobin plays an important role in the diagnosis and monitoring of poisoning, but its use should only be limited to healthcare professionals experienced with this biomarker.

Metmyoglobin Metmyoglobin is a derivative of the myohemoglobin polypeptide myoglobin (MG), containing an atom of a trivalent metal (iron in MG), which makes it unable to bind oxygen.

Normally, myoglobin requires a divalent oxygen atom to ensure normal functioning of the body without hypoxia. In the presence of toxic substances or other mechanisms that disrupt the full functioning of MG, the synthesis of trivalent iron atoms, including hemin iron, leads to suppression of MG function. In such a situation, MG cannot retain oxygen and forms full-fledged metmyoglo molecules