Michaelis Apparatus

The Michaelis apparatus is a laboratory device invented at the beginning of the 20th century by the German biochemist Leonor Michaelis (1875-1949). The apparatus was used to study the kinetics of enzymatic reactions.

The principle of operation of the apparatus was as follows: the enzyme under study and the substrate were placed in a test tube, which was inserted into a thermostated block. The products arising during the reaction were removed using absorption vessels. By measuring the rate of accumulation of products, it was possible to calculate the rate of the enzymatic reaction.

The use of the Michaelis apparatus made it possible to derive the basic kinetic equation of enzyme action, known as the Michaelis-Menten equation. It relates the rate of reaction to the concentration of the substrate. This equation is still widely used in fermentology.

Thus, the Michaelis apparatus played an important role in the development of biochemical science, making it possible for the first time to accurately study the kinetics of enzymatic reactions.

The Michaelis apparatus, located at the French Scientific Foundation, is the oldest successful apparatus in the world for histological research. The institute was founded in 1905 by R. Michelis, who became the first head of this laboratory and carried out the first successful staining operations using the “enzymatic” method. This device is recognized as one of the most important scientific discoveries, which contribute to a closer unification of biology and medicine, as well as the continuous development of histological science.

Mikhailis R., studying the influence of the thymus gland on the mucous membrane of the pharynx, was the first to note the movement of the epithelium of the mucous membrane into holes and gaps, indicating cell damage. Realizing this, he remembered that the tissues of the larynx, trachea and bronchi have faith