N-cholinergic receptors

N-cholinergic receptors (n-AChRs) are a group of receptors that respond to agonists such as nicotine, acetylcholine and other neurotransmitters. They are located in various tissues of the body, including the nervous system, muscle tissue and other organs.

H-AChRs are one of the main types of receptors involved in signal transmission in the nervous system. They play an important role in regulating various body functions such as muscle contraction, signal transmission between neurons, etc.

There are several types of n-ChRs in the human body, each of which has its own characteristics and functions. For example, muscarinic receptors (m-AChR), which are excited by acetylcholine, are located in the postsynaptic membranes of ganglions, while nicotinic receptors (n-AChR), which are also excited by acetylcholine and nicotine, are located at neuromuscular junctions.

nAChRs also play an important role in the development and functioning of the nervous system. For example, mutations in the genes encoding n-AChRs can lead to various diseases of the nervous system, such as Alzheimer's disease, Parkinson's disease, and others.

Thus, nAChRs play a key role in the functioning of the nervous system and are an important object of research in the field of pharmacology and medicine.

N-cholinergic reactors: Discovery, history and types

N-cholinergic receptors are one of the most important classes of receptors in humans and animals. They are proteins that accept neurotransmitter molecules (choline) and transmit a signal from one nerve cell to another. In this article we will talk about the history of the discovery of n-choline receptors and their classification, as well as how they work using the example of nicotine.

Discovery and history of research

The first known example of the n-cholinergic reactor was described in 1897 by researcher Ernest Hilmark. He discovered that selenium ion interfered with the action of morphine on opioid receptors. Later, in the 1960s, it was found that a substance that reacts to nicotine is located on the postsynaptic membranes of the peripheral ganglia. This protein was named nicotinic cholinoprexide because it converts nicotine in the central nervous system from the peripheral nervous system. Research over the following decades showed that n-cholines are present on various surfaces in the body and are involved in the transmission of nerve signals.

Classification

N-chloroline reactors are four types of proteins that have different properties and functions. We distinguish three types of receptors: M, N and p. • M-receptors - located only on the preganni