The Nissl primary response is a term from biology that refers to a specific reaction of body cells caused by various tissue damage or the development of pathology.
The primary Nissle reaction was named after the German histologist Erich Nissle, who first described the reaction in 1889. He drew attention to the change in color of the tissue section at the site of injury or inflammatory reaction, which was observed in various types of injury. Cells affected by this reaction were colored reddish, while older and damaged areas did not show this reaction, remaining colorless.
Interestingly, this reaction is one of the first examples of regulation of metabolism and tissue repair. It shows that cells are able to control their own metabolic processes and adapt to different environmental conditions.