Postsynaptic Potential Inhibitory

Postsynaptic inhibitory potentials Description Inhibitory postsynaptic potentials (IPSPs) constitute a class of nervous excitatory processes in which the membrane potential transitions from a value of one sign to a value of the opposite sign. IPSPs are widely distributed in the central nervous system and have different significance in higher animals and humans. For example, IPSPs are involved in the inhibition of reflex activity, regulation of the sleep-wake cycle, intestinal motility, ensure the resistance of nerve centers to hypoxia, that is, oxygen intoxication of the brain, and have protective properties against the action of glutamate and other toxic substances. One of the main representatives of the IPSP is the cochlear loop, which provides inhibition processes in the centers of the brain and spinal cord. The presynaptic part of the reflex axon of the cochlea ends on the cells of the inner ear (statocyte). In these cells, sensory input of the corresponding impulses occurs, which are then transmitted by presynaptic neurons to the internal auditory nervous system. In the synapses of the inner ear, glycine acts as a mediator. It enters the extracellular fluid, excites neuromuscular and smooth muscles, interacts with neurons of the auditory and vestibular parts of the central nervous system, and takes part in the regulation of blood pressure. It then interacts with specific receptors in nerve endings, which leads to the opening of chloride channels. This leads to membrane hyperpolarization and IPSP generation. It can be seen here that the development of IPSP directly depends on the activity of cAMP (cyclic AMP). According to the mechanism, IPSPs are associated with the formation of neurophysiological acetylcholine and contribute to the closure of Na^+ channels and an increase in the threshold of excitability. In humans and vertebrate mammals, the peripheral part of the IPSP arises in the cochlea of ​​the labyrinthine canal. In crustaceans (crayfish), these EPs occur near the nerve canals of the retina. TPS is a specific class of NPs described by the functions of potassium, calcium, sodium and magnesium.