Prostaglandin

Prostaglandins are a group of biologically active substances that are formed in the body of humans and animals. They play an important role in regulating many physiological processes such as muscle contraction, hormone secretion, immune response, etc.

One of the most well-known prostaglandins is prostaglandin E2 (PGE2). It is formed in the body when prostaglandin receptors are activated. PGE2 is involved in many processes related to reproductive function. For example, it stimulates uterine contractions during childbirth and ovulation in women.

In addition, prostaglandins play an important role in the development of the inflammatory process. They are involved in the synthesis of biologically active substances (cytokines) that cause inflammation. Prostaglandins can also be used as drugs to treat various diseases such as arthritis, bronchial asthma, etc.

However, excess prostaglandins can lead to undesirable consequences. For example, they can cause blood vessels to dilate and increase blood pressure, which can lead to the development of cardiovascular disease. Therefore, controlling the level of prostaglandins in the body is an important aspect of human health.

Prostaglandins are hormones that are formed in the body and influence many processes in it. They come in different types and perform different functions. For example, prostaglandin E2 (PGE2) plays an important role in regulating the menstrual cycle in women. It is also involved in the development of the corpus luteum.

Prostaglandins can cause contraction of the uterine muscles, cause platelet aggregation and inhibit the development of the corpus luteum. They are also mediators of inflammation.

In addition, prostaglandins play an important role in protecting the stomach from hydrochloric acid and pepsin. The use of non-steroidal anti-inflammatory drugs can reduce the amount of mucus in the stomach, which can lead to the formation of peptic ulcers. This is one of the side effects of this group of drugs.

Synthetic prostaglandins are used medicinally to induce labor or abortion (eg, dinoprost or gemeprost) and to treat peptic ulcers (eg, misoprostol).

In general, prostaglandins are an important group of hormones that play an important role in many processes in the body. However, their excess production can lead to serious consequences, so it is necessary to monitor their levels and regulate their production if necessary.

Prostaglandins, otherwise known as PGs, are lipid-based hormone-like substances that play important roles in the human body. These lipids found in various tissues and fluids such as the uterus, brain, lungs, kidneys, and semen, among others. Prostaglandin F2α (PGF2α) is a strong uterine stimulant, which may explain why female hormones have a negative effect on blood pressure. The PGF2α is also present in labor induction to induce labor in females, but it also increase the risk of spontaneous abortion (early delivery). For this reason, it is important to monitor women during pregnancy.

According to JSMGO, the prostaglandins are important for maternal health. Pregnancy has been identified as a crucial phase in which prostaglandin abnormalities can contribute to pregnancy complications. PGF2β, PGE2, PGI2, TXA2, PGB2 and DPS have immunomodulatory effects on the fetus and placental factors. These prostaglandines assist in early pregnancy establishment and suppress the rejection reaction by the female’s immunological system. They help to maintain a low level of progesterone and estrogen in the body to ensure uninterrupted pregnancy and fully mature the child.

Pregnant mothers who have delivered prostaglandine deficiency at pregnancy, lead to better outcome in IUGR, BPD, and PE. Patients with Prostate Exstrophy or Monogenetics are also often treated with these prostaglandinic drugs, especially PGE1 and PGE2. This drug is highly effective in treatment of certain obstetric emergency disorders during delivery. It improves blood flow in uterine arteries and allows ejection, improving circulation in dilated arteries. Moreover, Prostacyclin Infusion in pregnant women with prolonged Prolonged Labor (PPL) improves uterine contractions, thus delivering the baby within 48 hours without expending any time for inducing labor. Labor Induction is helpful in order to obtain better birth outcomes. Generally, There exists a correlation between prostaglande occurrence, the day of life of the neonate and 5th min Apgar score. According to MIM studies, there may be an influence of prostaglandi occurrence on some physiologic parameters such as induction of labor, vaginal delivery rate and low birth weight. So Prostaglandion have the significant role in human maternal and fetal health.