Ranitidine-Olaine

Country of origin - Russia

Pharm-Group - H2-histamine receptor blockers and similar agents

Manufacturers - Akrikhin HFC (Russia)

International name - Ranitidine

Synonyms - Apo-Ranitidine, Asitek, Acidex, Acylok, Acylok-E, Vero-Ranitidine, Gene-Ranitidine, Gertokalm, Gi-kar, Gistak, Duoran, Zantac, Zantin, Zoran, Neoseptin-R, Novo-Ranidin, Peptoran, Raniberl, Ranigast, Ranisan, Ranitab, Ranital, Ranitard, Ranitidine, Ranitidine S

Dosage forms - film-coated tablets 150 mg

Composition - Active ingredient - ranitidine.

Indications for use - Peptic ulcer of the stomach and duodenum, NSAID gastropathy, postoperative ulcers, reflux esophagitis, Zollinger-Ellison syndrome, chronic dyspepsia with epigastric and chest pain; prevention of stress ulcers, recurrent bleeding, Mendelssohn's syndrome.

Contraindications - Hypersensitivity, cirrhosis of the liver with a history of portosystemic encephalopathy, impaired liver and kidney function, pregnancy, lactation, children under 14 years of age.

Side effects - Headache, dizziness, vertigo, drowsiness, anxiety, agitation, depression, hallucinations, reversible blurred vision, involuntary movements, arrhythmias (tachycardia, bradycardia, asystole, AV block, extrasystole), constipation or diarrhea, nausea, vomiting, pain in the abdomen, pancreatitis, hepatocellular, cholestatic or mixed hepatitis with or without jaundice, arthralgia and myalgia, increased creatinine in the blood, leukopenia, granulocytopenia, thrombocytopenia, agranulocytosis, pancytopenia, bone marrow hypoplasia and aplastic anemia, immune hemolytic anemia, gynecomastia, impotence , decreased libido, alopecia, rash, erythema multiforme, angioedema, anaphylaxis.

Interactions - Antacids and sucralfate may reduce absorption. Changes the absorption and excretion of other drugs.

Overdose - Treatment: induction of vomiting or gastric lavage, for convulsions - IV diazepam, for bradycardia - atropine, for ventricular arrhythmias - lidocaine.

Special instructions - Use with caution in patients with impaired renal function, with porphyria (history) and in children. Before starting treatment, the presence of malignant neoplasms in the stomach and duodenum should be excluded. In elderly patients with impaired liver or kidney function, a disorder (confusion) of consciousness may occur, necessitating a dose reduction. Fast-dissolving tablets contain sodium, which must be taken into account when prescribing to patients who need to limit their intake, and aspartame, which is undesirable for patients with phenylketonuria.

Literature - Encyclopedia of Medicines 2006