Retrovir Azi Ti

Retrovir AZi Ti

Country of origin - UK

Pharm-Group - Antiviral - nucleosides

Manufacturers - Glaxo Wellcome (UK)

International name - Zidovudine

Synonyms - Azidotimidine (Timazid), Zidovudine-Ferein, Retrovir, Timazid (Azidothymidine)

Dosage forms - capsules 100 mg, solution for infusion 200 mg

Composition - Active substance - zidovudine.

Indications for use - Azidotimidine in combination with other antiretroviral drugs is used to treat HIV infection in adults and children.

Contraindications - Hypersensitivity, leukopenia (neutrophil count below 750/μl), anemia (hemoglobin content less than 7.5 g/dl), thrombocytopenia (decrease in platelet count to 25,000/μl), renal and/or liver failure (cirrhosis, chronic hepatitis). Relative contraindications to the use of the drug are vomiting and severe nausea. Children (up to 3 years).

Side effect - Anemia (requiring discontinuation/reduction of the dosage of the drug, sometimes there is a need for blood transfusions), neutropenia and leukopenia, dyspeptic disorders (nausea, vomiting, lack of appetite, abdominal pain, diarrhea, flatulence), increased blood activity of “liver” transaminases , hypercreatininemia, increased serum amylase activity, fever, development of secondary infection, headache, rash, muscle pain, paresthesia, insomnia, discomfort, asthenia, drowsiness, taste disturbance, cardialgia, depression, increased urination, chills, cough.

Interaction - Concomitant use of paracetamol with zidovudine increases the incidence of neutropenia, apparently due to inhibition of the metabolism of zidovudine (both drugs are glucuronidated). Other drugs (acetylsalicylic acid, morphine, codeine, indomethacin, oxazepam, cimetidine, clofibrate) also alter the metabolism of zidovudine by inhibiting glucuronidase activity or directly inhibiting microsomal metabolism in the liver. Simultaneous treatment with drugs that have nephrotoxic effects or suppress bone marrow function (pentamidine, amphotericin, ganciclovir, vincristine, vinblastine, etc.) increases the risk of toxic effects of zidovudine.

Overdose - No information.

Special instructions - It is necessary to systematically conduct studies of peripheral blood. The drug should be prescribed with extreme caution to patients with renal and liver failure, as well as elderly patients; in these cases, it is recommended to adjust the dosage regimen depending on the dynamics of the drug concentration in the blood.

Literature - Encyclopedia of Medicines 2002, Encyclopedia of Medicines 2002, Encyclopedia of Medicines 2002.