Stroma

Stromas are unique formations in the parenchyma of most epithelial lung tumors. They consist of a cuboidal connective tissue mass filled with hemosiderophages and macrophages that produce metalloproteases and oxidase. The most important function of macrophages in the lung stroma is the utilization of autophagically degenerated tumor cells, metabolites of tumor metabolism and other tissue products, including even mineral components of the fasting environment. In an effort to maximize utilization, epithelial cells, which are under mechanical pressure from neighboring stromal cells, progressively reduce the density of chromosomal DNA,