Tetanolysin

Tetanolysin is a substance that is formed as a result of the destruction of red blood cells under the action of tetanospasmin (phosphodiesterase). Tetanospasmin is a toxin produced by the bacteria Clostridium tetani. Tetanolysin plays an important role in the development of tetanus, as it is one of the factors responsible for the development of seizures.

When Clostridium tetani bacteria enter the human body, they begin to produce tetanospasmin. This toxin destroys red blood cells, resulting in the release of tetanolysin. Tetanolysin then binds to receptors on neurons and causes them to hyperpolarize, which in turn leads to the development of seizures.

Tetanolysin also plays an important role in the body's immune response to bacterial infection. It stimulates antibody production and phagocytosis, which helps fight infection.

However, tetanolysin may be hazardous to human health. If its level in the blood becomes too high, it can lead to disruption of the nervous system and other serious diseases. Therefore, it is important to monitor the level of tetanolysin in the blood and take measures to reduce it if necessary.

**"Tetanolysins"**

Tetanolysin is a natural compound formed in the blood of lead poisoning in workers involved in lead processing. This compound is also called “tetanohemolysin” because it simultaneously has the ability to cause hematoma and relieve spasm. Lead poisoning is fraught with problems of the human cardiovascular system, because it is precisely this effect that is caused by tetanolysine. There are different types of tetanolysins, and they are all united by a common mechanism of action on the body. The reason for their formation is the complex effect of lead on the walls of blood vessels. The tetany that develops manifests itself as follows:

1. formation of a blood clot in small capillaries in damaged areas; 2. coagulation of blood, disruption of its movement through the vessels of the body due to the displacement of the liquid consistency of blood from the circulatory system into damaged vessels; 3. decreased pressure in the veins of the legs with impaired filling of the veins with blood flow through them. As a result of this, loss of consciousness is possible with the transition to secondary shock after the acute period of the lesion.

In acute cases of lead poisoning, the duration of treatment can last 5, and sometimes up to 30 days. In the chronic form of poisoning, the course of treatment increases to several months, which is explained by the occurrence of high concentrations of toxic substances in the body. This makes it impossible to completely remove lead from the human body.

This pathology and syndrome are life-threatening, and the danger is especially high for children. If a person develops tetanhemolysis, then in such cases there is a possibility of coma with severe neurological symptoms. Toxicologists consider tetanum and its compounds as one of the main problems that arise during human interaction with toxic substances. This leads to the conclusion that it is necessary to improve the methodology for determining metal poisons and to clearly classify all compounds according to their effect on human health. Separately, the prevention of lead intoxication in humans should be considered; it is especially important to carry it out after hazardous industries, the work of which involves the use of lead salts. Ruthless treatment of diseases with lead drugs must be carried out correctly, taking into account the contraindications of a particular medication. Particular attention should be paid to the ability to restore hematopoiesis in cases of severe damage to the walls of blood vessels from toxic metals.